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Titolo:
Molecular physiology of neuronal K-ATP channels
Autore:
Liss, B; Roeper, J;
Indirizzi:
Univ Oxford, MRC, Anat Neuropharmacol Unit, Oxford OX1 3TH, England Univ Oxford Oxford England OX1 3TH armacol Unit, Oxford OX1 3TH, England
Titolo Testata:
MOLECULAR MEMBRANE BIOLOGY
fascicolo: 2, volume: 18, anno: 2001,
pagine: 117 - 127
SICI:
0968-7688(200104/06)18:2<117:MPONKC>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENSITIVE POTASSIUM CHANNELS; NIGRA PARS-RETICULATA; DORSAL VAGAL NEURONS; PROTEIN-KINASE-C; VENTROMEDIAL HYPOTHALAMIC NEURONS; DOPAMINERGIC MIDBRAIN NEURONS; SULFONYLUREA BINDING-SITES; HIPPOCAMPAL CA1 NEURONS; LOCUS-COERULEUS NEURONS; MAMMALIAN-CELL LINE;
Keywords:
K-ATP channels; single-cell RT-PCR; glucose sensing; ischemia; Parkinson's disease;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
144
Recensione:
Indirizzi per estratti:
Indirizzo: Roeper, J Univ Oxford, MRC, Anat Neuropharmacol Unit, Mansfield Rd, OxfordOX1 3TH, England Univ Oxford Mansfield Rd Oxford England OX1 3TH X1 3TH, England
Citazione:
B. Liss e J. Roeper, "Molecular physiology of neuronal K-ATP channels", MOL MEMBR B, 18(2), 2001, pp. 117-127

Abstract

ATP sensitive potassium (K-ATP) channels are widely expressed in many celltypes including neurons. K-ATP channels are heteromeric membrane proteins that consist of two very different subunits: the pore-forming, two-transmembrane spanning potassium channel subunit (Kir6) and the regulatory, 17 transmembrane spanning sulphonylurea receptor (SUR). This ensemble-joined together in a 4:4 stoichiometry-endows this channel with a unique combination offunctional properties. The open probability of K-ATP channels directly depends on the intracellular ATP/ADP levels allowing the channels to directly couple the metabolic state of a cell to its electrical activity. Here, recent progress on the molecular composition and functional diversity of neuronal K-ATP channels is reviewed. One is particular concerned with single-cellmRNA expression studies that give insight to the coexpression patterns of Kir6 and SUR isoforms in identified neurons. In addition, the physiologicalroles of neuronal K-ATP channels in glucose sensing and adapting neuronal activity to metabolic demands are discussed, as well as their emerging pathophysiological functions in acute brain ischemia and chronic neurodegenerative diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 06:21:20