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Titolo:
The yeast protein interaction network evolves rapidly and contains few redundant duplicate genes
Autore:
Wagner, A;
Indirizzi:
Univ New Mexico, Dept Biol, Albuquerque, NM 87131 USA Univ New Mexico Albuquerque NM USA 87131 Biol, Albuquerque, NM 87131 USA Santa Fe Inst, Santa Fe, NM 87501 USA Santa Fe Inst Santa Fe NM USA 87501Santa Fe Inst, Santa Fe, NM 87501 USA
Titolo Testata:
MOLECULAR BIOLOGY AND EVOLUTION
fascicolo: 7, volume: 18, anno: 2001,
pagine: 1283 - 1292
SICI:
0737-4038(200107)18:7<1283:TYPINE>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
SACCHAROMYCES-CEREVISIAE; FUNCTIONAL REDUNDANCY; SMALL-WORLD; DROSOPHILA; EVOLUTION; SELECTION; ORGANIZATION; INFORMATION; EXPRESSION; DIVERGENCE;
Keywords:
protein network; evolution; Saccharomyces cerevisiae; yeast; gene duplication;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Wagner, A Univ New Mexico, Dept Biol, 167A Castetter Hall, Albuquerque, NM87131 USA Univ New Mexico 167A Castetter Hall Albuquerque NM USA 87131 USA
Citazione:
A. Wagner, "The yeast protein interaction network evolves rapidly and contains few redundant duplicate genes", MOL BIOL EV, 18(7), 2001, pp. 1283-1292

Abstract

In this paper, the structure and evolution of the protein interaction network of the yeast Saccharomyces cerevisiae is analyzed. The network is viewed as a graph whose nodes correspond to proteins Two proteins are connected by an edge if they interact. The network resembles a random graph in that it consists of many small subnets (groups of proteins that interact with each ether but do not interact with any other protein) and one large connectedsubnet comprising more than half of all interacting proteins. The number of interactions per protein appears to follow a power law distribution. Within approximately 200 Myr after a duplication, the products of duplicate genes become almost equally likely to (1) have common protein interaction partners and (2) be part of the same subnetwork as two proteins chosen at random from within the network. This indicates that the persistence of redundantinteraction partners is the exception rather than the rule. After gene duplication, the likelihood that an interaction gets lost exceeds 2.2 X 10(-3)/Myr. New interactions are estimated to evolve at a rate that is approximately three orders of magnitude smaller. Every 300 Myr, as many as half of all interactions may be replaced by new interactions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 20:59:46