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Titolo:
Arrested testis development in the cpk mouse may be the result of abnormalsteroid metabolism
Autore:
Aziz, N; Anderson, E; Lee, GY; Woo, DDL;
Indirizzi:
Harvard Univ, Sch Med, Childrens Hosp, Dept Med,Nephrol Div, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 pt Med,Nephrol Div, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 h Med, Dept Pediat, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 ed, Dept Cell Biol, Boston, MA 02115 USA Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90095 USA Univ Calif LosAngeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA
Titolo Testata:
MOLECULAR AND CELLULAR ENDOCRINOLOGY
fascicolo: 1-2, volume: 171, anno: 2001,
pagine: 83 - 88
SICI:
0303-7207(20010122)171:1-2<83:ATDITC>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYCYSTIC KIDNEY-DISEASE; EXPRESSION; KE-6; GENE; TESTOSTERONE; APOPTOSIS;
Keywords:
polycystic kidney disease; reproductive; Ke 6; 17-beta hydroxysteroid dehydrogenase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Aziz, N Zycos Inc, 763E Concord Ave, Cambridge, MA 02138 USA Zycos Inc 763E Concord Ave Cambridge MA USA 02138 ge, MA 02138 USA
Citazione:
N. Aziz et al., "Arrested testis development in the cpk mouse may be the result of abnormalsteroid metabolism", MOL C ENDOC, 171(1-2), 2001, pp. 83-88

Abstract

Ke 6 is a 17 beta -hydroxysteroid dehydrogenase that is expressed in several somatic tissues as well as the female reproductive polycystic kidney disease. in three murine models, the cpk, jck and pcy mice. We also determinedthat in one of the murine models, the cpk mouse, the female reproductive organs fail to mature properly and remain arrested at an early stage of development. In this study, we report the expression of the Ke 6 protein in normal male reproductive tissues by immunofluorescent staining. We determined in the cpk mouse that the testes similar to the immature ovaries, is also under-developed and arrested at an early developmental stage. Direct measurement of 17 beta HSD activity showed a conspicuous reduction in sex steroid metabolism in the cpk:cpk testes. Our findings suggest that estrogen/androgen metabolism play an important role in the development of the urogenital system. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 15:50:50