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Titolo:
Grading of acute and chronic renal lesions in Henoch-Schonlein purpura
Autore:
Szeto, CC; Choi, PCL; To, KF; Li, PKT; Hui, J; Chow, KM; Leung, CB; Lui, SF; Lai, FMM;
Indirizzi:
Chinese Univ Hong Kong, Prince Wales Hosp, Dept Anat & Cellular Pathol, Shatin, Hong Kong, Peoples R China Chinese Univ Hong Kong Shatin Hong Kong Peoples R China Peoples R China Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China Chinese Univ Hong Kong Shatin Hong Kong Peoples R China Peoples R China Chinese Univ Hong Kong, Prince Wales Hosp, Dept Pediat, Shatin, Hong Kong,Peoples R China Chinese Univ Hong Kong Shatin Hong Kong Peoples R China ,Peoples R China
Titolo Testata:
MODERN PATHOLOGY
fascicolo: 7, volume: 14, anno: 2001,
pagine: 635 - 640
SICI:
0893-3952(200107)14:7<635:GOAACR>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
EARLY IGA NEPHROPATHY; NEPHRITIS; CHILDREN; DISEASE; ADULTS;
Keywords:
acute renal lesions; chronicity-based grading; Henoch-Schonlein purpura; histological grading; primary IgA nephropathy; prognosis; renal biopsy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Lai, FMM Chinese Univ Hong Kong, Prince Wales Hosp, Dept Anat & Cellular Pathol, Room 34055, Shatin, Hong Kong, Peoples R China Chinese Univ Hong Kong Room 34055 Shatin Hong Kong Peoples R China
Citazione:
C.C. Szeto et al., "Grading of acute and chronic renal lesions in Henoch-Schonlein purpura", MOD PATHOL, 14(7), 2001, pp. 635-640

Abstract

The renal outcome of 34 patients with Henoch-Schonlein purpura nephritis was assessed clinically and by grading acute and chronic renal lesions usinga system we applied to primary IgA nephropathy. On a median follow-up period of 65 months, hypertension and the serum levels of creatinine and proteinuria at the time of renal biopsy were correlated with renal survival. Acute glomerular lesions including mesangial hypercellularity, endocapillary proliferation, necrosis, cellular crescents, and leukocytes infiltration wereobserved, respectively, in 41%, 12%, 50%, 29%, and 32% of the cases. Of these, only glomerular necrotizing lesion and cellular crescent were correlated with the renal survival. Chronic renal lesions based on a grading systemapplied to primary IgA nephropathy and assessing the extent of glomerular sclerosis (glomerular grading), of tubular loss and interstitial fibrosis (tubulointerstitial grading), and of hyaline arteriolosclerosis demonstratedcorrelation between these lesions, as well as with renal survival. On follow-up, these chronic renal lesions were predictors of subsequent clinical events associated with disease progression, such as impaired renal function,significant proteinuria, and development of hypertension. Despite some limitations related to the relatively small size, this series indicates that distinction of acute and chronic lesions of Henoch-Schonlein purpura nephritis is important for both the prognosis and management of patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 16:07:08