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Titolo:
Bronchodilating response in elderly patients.
Autore:
Quadrelli, SA; Roncoroni, AJ; Sacerdotti, A;
Indirizzi:
Univ Buenos Aires, Fac Med, Inst Invest Med Alfredo Lanari, RA-1427 BuenosAires, DF, Argentina Univ Buenos Aires Buenos Aires DF Argentina RA-1427 sAires, DF, Argentina Univ Buenos Aires, Fac Ingn, Dept Estadist, RA-1427 Buenos Aires, DF, Argentina Univ Buenos Aires Buenos Aires DF Argentina RA-1427 Aires, DF, Argentina
Titolo Testata:
MEDICINA-BUENOS AIRES
fascicolo: 3, volume: 61, anno: 2001,
pagine: 257 - 261
SICI:
0025-7680(2001)61:3<257:BRIEP>2.0.ZU;2-G
Fonte:
ISI
Lingua:
SPA
Soggetto:
AIR-FLOW OBSTRUCTION; NONSPECIFIC BRONCHIAL RESPONSIVENESS; LUNG-FUNCTION; ASTHMA; AGE; REVERSIBILITY; DISEASE; METHACHOLINE; IPRATROPIUM; SALBUTAMOL;
Keywords:
elderly patients; bronchodilators; asthma; EPOC; reversibility;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Quadrelli, SA Univ Buenos Aires, Fac Med, Inst Invest Med Alfredo Lanari, Combatientes Malvinas 3150, RA-1427 Buenos Aires, DF, Argentina Univ BuenosAires Combatientes Malvinas 3150 Buenos Aires DF Argentina RA-1427
Citazione:
S.A. Quadrelli et al., "Bronchodilating response in elderly patients.", MEDICINA, 61(3), 2001, pp. 257-261

Abstract

Asthma in the elderly is more severe and a decreased bronchodilating response has been suggested as a contributing factor. There is no agreement on the best way of expressing reversibility. The aim of this study was to evaluate bronchodilator response in elderly patients with asthma with different levels of airway obstruction and expressing reversibility by different indices. A total of 72 asthmatic patients were studied: (FEV1/FVC < 1.64 SEE below predicted). Two groups were considered: Group I: greater than or equal to 65 years (71.0 +/- 11.7 years; FEV1 54.0 +/- 16.7% of predicted) and Group II: < 40 years (23.0 +/- 7.7 years, FEV1 67.6 +/- 16.1%). Response to bronchodilators expressed as Delta absolute, Delta %predicted or Delta %maximal was not different between the two groups. Reversibility expressed as Delta %initial, however, was lower in younger patients (> 65 years: 22.2 +/- 16.6% vs < 40 years: 11.8 +/- 9.9%, p = < 0.005). A covariance analysis was performed using baseline FEV1 as covariate and bronchodilator response was not different between the two groups. Neither Delta absolute (r = 0.13, p =NS), Delta %predicted (r = 0.06, p = NS) nor Delta maximal (r = 0.09, p = NS) showed correlation with age. Delta %initial showed weak but significantcorrelation with age (r = 0.28, p = < 0.05) and marked dependence on baseline FEV1 (r = 0.47, p = < 0.001). Bronchodilator reversibility in the elderly asthmatics is preseved. Expressing reversibility as Delta %initial produces differences depending on baseline airway obstruction.

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Documento generato il 22/02/20 alle ore 18:12:19