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Titolo:
Hyperactivity in a mouse model of the antiphospholipid syndrome
Autore:
Katzav, A; Pick, CG; Korczyn, AD; Oest, E; Blank, M; Shoenfeld, Y; Chapman, J;
Indirizzi:
Tel Aviv Univ, Sackler Fac Med, Dept Physiol & Pharmacol, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 rmacol, IL-69978 Tel Aviv, Israel Tel Aviv Univ, Sackler Fac Med, Dept Anat, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 t Anat, IL-69978 Tel Aviv, Israel Tel Aviv Univ, Sackler Fac Med, Dept Neurol, IL-69978 Tel Aviv, Israel TelAviv Univ Tel Aviv Israel IL-69978 Neurol, IL-69978 Tel Aviv, Israel Chaim Sheba Med Ctr, Dept Med B, IL-52621 Tel Hashomer, Israel Chaim ShebaMed Ctr Tel Hashomer Israel IL-52621 21 Tel Hashomer, Israel Chaim Sheba Med Ctr, Autoimmune Dis Res Unit, IL-52621 Tel Hashomer, Israel Chaim Sheba Med Ctr Tel Hashomer Israel IL-52621 21 Tel Hashomer, Israel Tel Aviv Univ, Sackler Fac Med, Dept Biochem, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 iochem, IL-69978 Tel Aviv, Israel
Titolo Testata:
LUPUS
fascicolo: 7, volume: 10, anno: 2001,
pagine: 496 - 499
SICI:
0961-2033(2001)10:7<496:HIAMMO>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYSTEMIC LUPUS-ERYTHEMATOSUS; MICE FOLLOWING IMMUNIZATION; ANTICARDIOLIPIN ANTIBODIES; GLYCOPROTEIN-I; APOLIPOPROTEIN-H; DISEASE; INDUCTION; COFACTOR; ANTI-BETA(2)-GLYCOPROTEIN-I; MANIFESTATIONS;
Keywords:
antiphospholipid syndrome; Chi 2-glycoprotein-I (apolipoprotein H); animal model; staircase test; behavior;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Chapman, J Tel Aviv Univ, Sackler Fac Med, Dept Physiol & Pharmacol, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 69978 Tel Aviv, Israel
Citazione:
A. Katzav et al., "Hyperactivity in a mouse model of the antiphospholipid syndrome", LUPUS, 10(7), 2001, pp. 496-499

Abstract

In the antiphospholipid syndrome (APS), antibodies to a complex of phospholipids and beta2-glycoprotein I (beta (2)-GPI) are associated with recurrent thromboembolic events, spontaneous abortions, thrombocytopenia and central nervous system (CNS) disturbances. Animals immunized with beta (2)-GPI develop the systemic manifestations of APS but the involvement of the (CNS) in these animals has not been studied. The objective of the present study was to examine mice with induced experimental APS for behavioral changes. Female Balb/C mice were immunized once with beta (2)-GPI in complete Freund's adjuvant (CFA) or with CFA alone. Four months after immunization the mice were tested in the staircase apparatus and the following two variables were measured: (1) number of rears; and (2) number of stairs climbed by the mice. Immunization with beta (2)-GPI resulted in elevated levels of circulatinganti-negatively charged phospholipids and anti-beta (2)-GPI antibodies. The APS mice exhibited hyperactive behavior as reflected by more frequent rears (P < 0.023) and higher number of stairs climbed (P < 0.019) by the mice in 3 min. This simple test demonstrated that experimental APS animals are significantly hyperactive and may serve as a marker for CNS involvement in this model.

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Documento generato il 05/08/20 alle ore 10:05:03