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Titolo:
Control of mammary involution by insulin-like growth factor binding proteins: role of prolactin
Autore:
Flint, DJ; Tonner, E; Knight, CH; Whitelaw, CBA; Webster, J; Barber, M; Allan, G;
Indirizzi:
Hannah Res Inst, Ayr KA6 5HL, Scotland Hannah Res Inst Ayr Scotland KA6 5HL nah Res Inst, Ayr KA6 5HL, Scotland Roslin Inst, Roslin EH25 9PS, Midlothian, Scotland Roslin Inst Roslin Midlothian Scotland EH25 9PS 9PS, Midlothian, Scotland
Titolo Testata:
LIVESTOCK PRODUCTION SCIENCE
fascicolo: 1-2, volume: 70, anno: 2001,
pagine: 115 - 120
SICI:
0301-6226(200107)70:1-2<115:COMIBI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR MESSENGER-RNA; FACTOR-I; HORMONE RECEPTOR; PLASMINOGEN-ACTIVATOR; PANCREATIC HORMONES; GLAND DEVELOPMENT; GENE-EXPRESSION; LACTATING GOATS; MILK SECRETION; IGF SYSTEM;
Keywords:
prolactin; insulin-like growth factor binding proteins; growth hormone; mammary gland; galactopoiesis; cell proliferation; cell differentiation; apoptosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Flint, DJ Hannah Res Inst, Ayr KA6 5HL, Scotland Hannah Res Inst Ayr Scotland KA6 5HL st, Ayr KA6 5HL, Scotland
Citazione:
D.J. Flint et al., "Control of mammary involution by insulin-like growth factor binding proteins: role of prolactin", LIVEST PROD, 70(1-2), 2001, pp. 115-120

Abstract

The insulin-like growth factor binding proteins (IGFBPs) constitute a family of proteins which modulate the activity of the IGFs. IGF-I is an important survival factor for mammary epithelial cells and overexpression of IGF-Iin the mammary glands of lactating mice can delay involution. We have shown that the mouse, rat and pig mammary gland produces IGFBP-5 during the early stage of mammary involution and we proposed that the function of this binding protein is to inhibit IGF-mediated cell survival and thereby to induce apoptotic cell death. Prolactin is a potent inhibitor of IGFBP-5 expression and we believe this is an important aspect of its anti-apoptotic effect. Subsequently we have shown that over expression of IGFBP-5 in the mammary gland of lactating mice leads to impaired milk production, with a reductionin the number of mammary epithelial cells. The precise mechanism by which this occurs is currently under investigation. In ovine and bovine mammary gland IGFBP-5 is not yet implicated although IGFBP-3 concentrations increasein cows during mammary involution and it is possible that IGFBP-3 serves this function in ruminants. In addition, the IGFBPs have been shown to interact with several proteins present in milk including alpha (s2)-casein, lactoferrin and transferrin. These interactions implicate the IGFBPs in the regulation of plasminogen activation since plasminogen and t-PA also bind to alpha (s2)-casein. This is a key process in tissue remodelling although, at the moment, no unifying hypothesis exists with regard to the nature of these interactions. Some studies have suggested that these interactions of IGFBPs with milk proteins lead to increased growth factor availability whereas others suggest that this serves to function as a means of sequestering IGF-I from its receptor. Whatever their role, it is clear that the IGFBPs play an important role in mammary gland function. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/01/20 alle ore 19:59:08