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Titolo:
Influence of tumor characteristics on the outcome of liver transplantationamong patients with liver cirrhosis and hepatocellular carcinoma
Autore:
Herrero, JI; Sangro, B; Quiroga, J; Pardo, F; Herraiz, M; Cienfuegos, JA; Prieto, J;
Indirizzi:
Clin Univ, Liver Unit, Pamplona 31008, Spain Clin Univ Pamplona Spain 31008 n Univ, Liver Unit, Pamplona 31008, Spain Clin Univ, Dept Surg, Pamplona 31008, Spain Clin Univ Pamplona Spain 31008 in Univ, Dept Surg, Pamplona 31008, Spain
Titolo Testata:
LIVER TRANSPLANTATION
fascicolo: 7, volume: 7, anno: 2001,
pagine: 631 - 636
SICI:
1527-6465(200107)7:7<631:IOTCOT>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLASSIFICATION; RESECTION; CHEMOTHERAPY; RECURRENCE; SURVIVAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Herrero, JI Clin Univ, Liver Unit, Av Pio XII S-N, Pamplona 31008, Spain Clin Univ Av Pio XII S-N Pamplona Spain 31008 na 31008, Spain
Citazione:
J.I. Herrero et al., "Influence of tumor characteristics on the outcome of liver transplantationamong patients with liver cirrhosis and hepatocellular carcinoma", LIVER TRANS, 7(7), 2001, pp. 631-636

Abstract

Hepatocellular carcinoma (HCC) may recur after liver transplantation (LT),mainly in patients with multinodular and large tumors. However, factors predictive of outcome after LT in patients with small tumors remain ill defined. We investigated which factors were related to mortality or tumor recurrence among 47 liver transplant recipients with liver cirrhosis and HCC and compared them with 107 patients with liver cirrhosis without tumor who underwent LT in the same period. Patients with HCC were older (P < .001), more frequently had cirrhosis of a viral origin (P < .001), and had lower Child-Pugh scores (P < .001) than patients without tumor. Survival of patients with and without tumor was not significantly different (P = .20). Among patients with HCC, those with lower recurrence-free survival rates had liver cirrhosis of a viral origin, vascular invasion, bilobar disease, and tumor-node-metastasis (TNM) stage IV. At multivariate analysis, the only factor associated with. mortality or recurrence was TNM stage IV (P = .02). Our results suggest that in patients with HCC and TNM stage TV, LT might be contraindicated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/02/20 alle ore 21:29:34