Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Frequency of nonalcoholic steatohepatitis as a cause of advanced liver disease
Autore:
Charlton, M; Kasparova, P; Weston, S; Lindor, K; Maor-Kendler, Y; Wiesner, RH; Rosen, CB; Batts, KP;
Indirizzi:
Mayo Clin & Mayo Fdn, Dept Gastroenterol & Hepatol, Liver Transplant Unit,Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 Unit,Rochester, MN 55905 USA
Titolo Testata:
LIVER TRANSPLANTATION
fascicolo: 7, volume: 7, anno: 2001,
pagine: 608 - 614
SICI:
1527-6465(200107)7:7<608:FONSAA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC ACTIVE HEPATITIS; CRYPTOGENIC CIRRHOSIS; FATTY LIVER; ALPHA-1-ANTITRYPSIN DEFICIENCY; ALCOHOLIC STEATOHEPATITIS; NATURAL-HISTORY; RISK-FACTORS; OBESITY; PREVALENCE; STEATOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Charlton, M Mayo Clin & Mayo Fdn, Dept Gastroenterol & Hepatol, Liver Transplant Unit,Eisenberg 2-G,200 1st St SW, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Eisenberg 2-G,200 1st St SW Rochester MN USA 55905
Citazione:
M. Charlton et al., "Frequency of nonalcoholic steatohepatitis as a cause of advanced liver disease", LIVER TRANS, 7(7), 2001, pp. 608-614

Abstract

Although nonalcoholic steatohepatitis (NASH) has generally been considereda benign condition, the increasing prevalence and severity of obesity has heightened concerns about the frequency with which NASH progresses to end-stage liver disease. The aim of this study is to determine the frequency clinical features, and posttransplantation history of decompensated liver disease secondary to NASH. The frequency of NASH as a cause of end-stage liver disease was prospectively determined in patients evaluated for liver transplantation. NASH was considered to be the primary cause of liver disease in patients who had histological evidence of steatohepatitis and in whom chronic liver diseases other than NASH were excluded. Posttransplantation histological characteristics were also determined in patients with NASH and compared with those of patients with pretransplantation diagnoses of cholestaticliver diseases, alcoholic disease, and hepatitis C. Of 1,207 patients evaluated for liver transplantation during the study period, 31 patients (2.6%)had NASH as the primary cause of liver disease. In the same period, 546 liver transplantations were performed, 16 of which (2.9%) were for end-stage disease secondary to NASH. Posttransplantation steatosis was seen in 60% oftransplant recipients with NASH versus 5% of those with cholestatic disease,; 15% of those with alcoholic disease, and 15% of those with hepatitis C. Steatohepatitis recurred in 33% of transplant recipients with NASH, with progression to cirrhosis in 12.5%. NASH can progress to end-stage liver disease in a minority of affected patients and was the primary cause of liver disease in 2.9% of patients evaluated for Liver transplantation at oar center, Recurrence of steatosis and NASH is frequent and can be severe after liver transplantation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 00:51:20