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Titolo:
Carbetapentane attenuates kainate-induced seizures via sigma-1 receptor modulation
Autore:
Kim, HC; Jhoo, WK; Kim, WK; Shin, EJ; Cheon, MA; Shin, CY; Ko, KH;
Indirizzi:
Kangweon Natl Univ, Coll Pharm, Korea Inst Drug Abuse, Dept Pharm Neurotoxicol Program, Chunchon 200701, South Korea Kangweon Natl Univ Chunchon South Korea 200701 nchon 200701, South Korea Ewha Univ, Sch Med, Ewha Inst Neurosci, Dept Pharmacol, Seoul, South KoreaEwha Univ Seoul South Korea eurosci, Dept Pharmacol, Seoul, South Korea Seoul Natl Univ, Coll Pharm, Dept Pharm, Seoul, South Korea Seoul Natl Univ Seoul South Korea Pharm, Dept Pharm, Seoul, South Korea
Titolo Testata:
LIFE SCIENCES
fascicolo: 8, volume: 69, anno: 2001,
pagine: 915 - 922
SICI:
0024-3205(20010713)69:8<915:CAKSVS>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUINEA-PIG BRAIN; KAINIC ACID; ANTICONVULSANT PROPERTIES; BINDING-SITES; DEXTROMETHORPHAN; EXPRESSION; RAT; HIPPOCAMPUS; BLOCKS;
Keywords:
carbetapentane; anticonvulsant; neuroprotection; kainic acid; seizures; sigma-1 receptor; Fos-related antigen immunoreactivity; hippocampus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Kim, HC Kangweon Natl Univ, Coll Pharm, Korea Inst Drug Abuse, Dept Pharm Neurotoxicol Program, Chunchon 200701, South Korea Kangweon Natl Univ Chunchon South Korea 200701 0701, South Korea
Citazione:
H.C. Kim et al., "Carbetapentane attenuates kainate-induced seizures via sigma-1 receptor modulation", LIFE SCI, 69(8), 2001, pp. 915-922

Abstract

We examined the effects of a non-opioid antitussive, carbetapentane (CB) on kainic acid (KA)induced neurotoxicity in rats. KA administration (10 mg/kg, i.p.) produced robust behavioral convulsions lasting 4 to 5 h. CB (12.5 and 25 mg/kg, i.p,) pretreatment consistently and in a dose-dependent manner reduced the KA-induced seizures, mortality, and marked loss of cells in regions CA1 and CA3 of the hippocampus. Consistently, CB pretreatment also significantly attenuated the KA-induced increase in Fos-related antigen immunoreactivity in the hippocampus, In contrast. pretreatment with the sigma -1 receptor antagonist BD1047 (1 and 2 mg/kg, i.p.) blocked, in a dose-related manner, the neuroprotection afforded by CB. These results suggest that CB provides neuroprotection against KA insult via sigma -1 receptor modulation. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 22:36:51