Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Podocyte injury predicts prognosis in patients with IgA nephropathy using a small amount of renal biopsy tissue
Autore:
Hishiki, T; Shirato, I; Takahashi, Y; Funabiki, K; Horikoshi, S; Tomino, Y;
Indirizzi:
Juntendo Univ, Sch Med, Dept Med, Div Nephrol,Bunkyo Ku, Tokyo 1138421, Japan Juntendo Univ Tokyo Japan 1138421 ephrol,Bunkyo Ku, Tokyo 1138421, Japan
Titolo Testata:
KIDNEY & BLOOD PRESSURE RESEARCH
fascicolo: 2, volume: 24, anno: 2001,
pagine: 99 - 104
SICI:
1420-4096(2001)24:2<99:PIPPIP>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLOMERULAR DAMAGE; GLOMERULONEPHRITIS; RAT;
Keywords:
morphometry; podocyte injury; prognosis; IgA nephropathy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Tomino, Y Juntendo Univ, Sch Med, Dept Med, Div Nephrol,Bunkyo Ku, Hongo 2-1-1, Tokyo 1138421, Japan Juntendo Univ Hongo 2-1-1 Tokyo Japan 1138421 yo 1138421, Japan
Citazione:
T. Hishiki et al., "Podocyte injury predicts prognosis in patients with IgA nephropathy using a small amount of renal biopsy tissue", KIDNEY BL P, 24(2), 2001, pp. 99-104

Abstract

To predict the progression in patients with IgA nephropathy, we analyzed glomerular lesions except for sclerosis, adhesion and/or crescents in 34 patients with this disease by morphometric analysis. Levels of urinary proteinexcretion (UP), creatinine clearance (Ccr), serum creatinine (sCr) and mean blood pressure (MBP) at the time of renal biopsy were used as the clinical parameters. The slope of 1/sCr was also used as a prognostic parameter. Renal specimens were obtained by echo-guided biopsy. In PAS-stained light microscopic renal sections, three midsections of open glomeruli were selectedand photographed, Stereologic estimation was performed as follows: absolute values of glomerular volume (V-G), glomerular surface area (S-G), podocyte and nonpodocyte cell number per glomerulus (N-G(pod) and NG(Non-pod)), glomerular surface area covered by one podocyte S-G/N-G(pod)) and glomerular volume occupied by one nonpodocyte cell (V-G/NG(Non-pod)) There was a significant correlation between the levels of UP and the change of podocyte injury parameters (N-G(pod) and S-G/N-G(pod)) or NG(Non-pod) N-G(pod) was negatively but S-G/N-G(pod) and NG(Non-pod) were positively correlated with UP. S-G/N-G(pod) or NG(Non-pod) was correlated with MBP. N-G(pod), S-G/ N-G(pod), NG(Non-pod), UP or MBP was significantly correlated with the slope of 1/sCr, High specificity was observed for N-G(pod), S-G/N-G(pod) and MBP. Highsensitivity was also observed for NG(Non-pod) and UP. It appears that podocyte injury might provide additional prognostic information in patients with IgA nephropathy. Copyright (C) 2001 S. Karger AG. Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 22:19:38