Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The reversal of xylazine hydrochloride by yohimbine and 4-aminopyridine ingoats
Autore:
Ndeereh, DR; Mbithi, PMF; Kihurani, DO;
Indirizzi:
Univ Nairobi, Fac Med Vet, Dept Clin Studies, Nairobi, Kenya Univ NairobiNairobi Kenya c Med Vet, Dept Clin Studies, Nairobi, Kenya
Titolo Testata:
JOURNAL OF THE SOUTH AFRICAN VETERINARY ASSOCIATION-TYDSKRIF VAN DIE SUID-AFRIKAANSE VETERINERE VERENIGING
fascicolo: 2, volume: 72, anno: 2001,
pagine: 64 - 67
SICI:
1019-9128(200106)72:2<64:TROXHB>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTAGONISM; ANESTHESIA; SEDATION;
Keywords:
small East African goats; xylazine antagonists; xylazine hydrochloride; yohimbine; 4-aminopyridine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Ndeereh, DR Kenya Wildlife Serv, Vet Unit, POB 40241, Nairobi, Kenya KenyaWildlife Serv POB 40241 Nairobi Kenya , Nairobi, Kenya
Citazione:
D.R. Ndeereh et al., "The reversal of xylazine hydrochloride by yohimbine and 4-aminopyridine ingoats", J SA VET AS, 72(2), 2001, pp. 64-67

Abstract

Yohimbine, 4-aminopyridine, and a combination of the 2 drugs were studied to assess their potential as antagonists to xylazine in goats. Twenty-four small East African goats were divided randomly into 4 groups of 6 goats each in a placebo-controlled study. They were all treated with intramuscular xylazine at 0.44 mg/kg. At the time of maximum sedation, sterile water was administered intravenously to the control group, 0.15% 4-aminopyridine at 0.4mg/kg to Group 2, 0.1% yohimbine at 0.25 mg/kg to Group 3, and the combination of the 2 drugs at the same dose rates to Group 4. The yohimbine/4-amino-pyridine combination was also used to antagonise xylazine at 0.88mg/kg in6 goats. The heart rate, respiratory rate and rate of ruminal movements, the pedal and palpehral reflexes as well as the reaction to noxious stimuli,the standing time and the total recovery time were established and evaluated to assess the effects of the treatments. The drugs reversed the xylazine-induced decrease in the heart rate, respiratory rate and rate of ruminal movements, and also rapidly restored the reflexes as well as the reaction tonoxious stimulation. In addition, they significantly (P < 0.05) decreased the mean standing time. The mean total recovery time was decreased significantly (P < 0.05) by 4-aminopyridine and the yohimbine/4-aminopyridine combination, but non-significantly (P <greater than> 0.05) by yohimbine. No relapse in sedation occurred. Overall, the combination of yohimbine and 4-aminopyridine produced better responses than the individual drugs, and may therefore be used for rapid reversal of xylazine-induced sedation in goats. Yohimbine or 4-aminopyridine may also be useful for this purpose but recovery may be prolonged.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 07:38:49