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Titolo:
Long-term experience with citalopram in the treatment of adolescent OCD
Autore:
Thomsen, PH; Ebbesen, C; Persson, C;
Indirizzi:
Aarhus Univ Hosp, Psychiat Hosp Children & Adolescents, DK-8240 Risskov, Denmark Aarhus Univ Hosp Risskov Denmark DK-8240 cents, DK-8240 Risskov, Denmark
Titolo Testata:
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
fascicolo: 8, volume: 40, anno: 2001,
pagine: 895 - 902
SICI:
0890-8567(200108)40:8<895:LEWCIT>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSESSIVE-COMPULSIVE-DISORDER; OPEN TRIAL; CHILDREN; CLOMIPRAMINE; SERTRALINE; PHENOMENOLOGY; RELIABILITY; FLUOXETINE; 2-YEAR; SCALE;
Keywords:
citalopram; long-term treatment; obsessive-compulsive disorder;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Thomsen, PH Aarhus Univ Hosp, Psychiat Hosp Children & Adolescents, HaraldSelmers Vej66, DK-8240 Risskov, Denmark Aarhus Univ Hosp Harald Selmers Vej 66 Risskov Denmark DK-8240
Citazione:
P.H. Thomsen et al., "Long-term experience with citalopram in the treatment of adolescent OCD", J AM A CHIL, 40(8), 2001, pp. 895-902

Abstract

Objective: The primary purpose of the study was to describe tolerability and effectiveness of citalopram in the treatment of adolescent obsessive-compulsive disorder (OCD). Method: Thirty nondepressed patients (15 females, 15 males) with a mean age of 13.7 years (range 13-18 years) were treated fortheir OCD with citalopram in an open-label, flexible-dose study (range of dose 20-70 mg; mean dose 46.5 mg). All patients were referred to Aarhus University Hospital. The patients were monitored for 1 to 2 years. The mean total score on the Yale-Brown Obsessive Compulsive Scale (child or adult version) was 28.7 at baseline, 23.3 after 10 weeks of treatment, 20.0 after 6 months, 18.4 after 1 year, and 17.9 after 2 years (from baseline to 2 years of treatment: t = 11.65; p < .001). Results: Seventy percent showed a decrease in total Yale-Brown Obsessive Compulsive Scale score in excess of 35% from baseline to 1 year of treatment. Twenty percent still had a score of greater than 20 after 1 year of treatment, indicating that clinically they still had OCD. Side effects were similar to those reported from the use of other selective serotonin reuptake inhibitors (SSRIs). No patient was excluded because of serious side effects during the 1 year of observation. Conclusions: The clinical effectiveness and tolerability of citalopram in the long-term treatment seem to be comparable with the observations of other SSRIs in childhood and adolescent OCD. A further, statistically significant reduction is provided by an extended treatment period of up to 1 year.

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Documento generato il 18/01/20 alle ore 01:43:03