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Titolo:
Aging-dependent changes in the effect of daily melatonin supplementation on rat metabolic and behavioral responses
Autore:
Rasmussen, DD; Mitton, DR; Larsen, SA; Yellon, SM;
Indirizzi:
Univ Washington, Mental Illness Res Educ & Clin Ctr, VA Puget Sound Hlth Care Syst, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 lth Care Syst, Seattle, WA 98195 USA Univ Washington, Dept Psychiat, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 Dept Psychiat, Seattle, WA 98195 USA Univ Washington, Dept Behav Sci & Med, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 hav Sci & Med, Seattle, WA 98195 USA Loma Linda Univ, Dept Physiol, Loma Linda, CA 92350 USA Loma Linda Univ Loma Linda CA USA 92350 Physiol, Loma Linda, CA 92350 USA
Titolo Testata:
JOURNAL OF PINEAL RESEARCH
fascicolo: 1, volume: 31, anno: 2001,
pagine: 89 - 94
SICI:
0742-3098(200108)31:1<89:ACITEO>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMA LEPTIN; VISCERAL FAT; PINEAL-GLAND; BODY-WEIGHT; FOOD-INTAKE; AGED RATS; INSULIN;
Keywords:
aging; insulin; leptin; melatonin; novelty; visceral fat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Rasmussen, DD VA Med Ctr, Res Serv 151, Amer Lake, Tacoma, WA 98493 USA VAMed Ctr Amer Lake Tacoma WA USA 98493 acoma, WA 98493 USA
Citazione:
D.D. Rasmussen et al., "Aging-dependent changes in the effect of daily melatonin supplementation on rat metabolic and behavioral responses", J PINEAL R, 31(1), 2001, pp. 89-94

Abstract

Pineal melatonin secretion has been reported to commonly decrease with aging, whereas intra-abdominal adiposity, plasma insulin and plasma leptin levels tend to increase. We recently demonstrated that daily melatonin administration starting at middle age suppressed male rat intra-abdominal fat, plasma leptin and plasma insulin to youthful levels, suggesting that aging-related changes in pineal melatonin secretion and in energy regulation may be functionally related. Accordingly, we have now investigated the effects of daily melatonin treatment on energy regulation in young versus middle-aged male Sprague-Dawley rats. Addition of melatonin to the drinking water (0.2 mug/mL) produced nocturnal and diurnal plasma melatonin concentrations in middle-aged rats (12 months) equivalent to those of young adult (5 months) rats. Administration of this melatonin dosage every day for 10 wk starting at 10 months of age suppressed (P < 0.01) relative intra-abdominal fat. non-fasted plasma insulin and plasma leptin by 27, 39, and 51%, respectively (vs. vehicle-treated controls). In contrast, administration of melatonin for 10 wk starting at 3 months of age did not significantly alter (P > 0.10) any of these parameters. The melatonin administration stimulated (102%, P < 0.001) behavioral responsiveness of the middle-aged rats in a test of response to novelty, restoring youthful levels, but did not significantly alter behavioral responsiveness of the young rats. These results suggest that suppression of intra-abdominal adiposity and plasma leptin and insulin levels and stimulation of behavioral responsiveness in response to daily exogenous melatonin begins at middle age, coincident with and likely dependent upon the aging-associated decline in endogenous pineal melatonin secretion. Theseresults further suggest that appropriate melatonin supplementation may potentially provide therapy or prophylaxis not only for the insulin resistance, increased intra-abdominal fat and resulting pathologies that occur with aging, but also for some aging-associated behavioral changes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 00:11:04