Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Synthesis and biological evaluation of destruxin A and related analogs
Autore:
Ast, T; Barron, E; Kinne, L; Schmidt, M; Germeroth, L; Simmons, K; Wenschuh, H;
Indirizzi:
Jerini Bio Tools GmbH, D-12489 Berlin, Germany Jerini Bio Tools GmbH Berlin Germany D-12489 bH, D-12489 Berlin, Germany Dupont Crop Protect, Stine Haskell Res Ctr, Newark, DE 19714 USA Dupont Crop Protect Newark DE USA 19714 ell Res Ctr, Newark, DE 19714 USA FMC Corp, Agr Prod Grp, Princeton, NJ 08543 USA FMC Corp Princeton NJ USA08543 rp, Agr Prod Grp, Princeton, NJ 08543 USA Humboldt Univ, Charite, Inst Med Immunol, Berlin, Germany Humboldt Univ Berlin Germany Charite, Inst Med Immunol, Berlin, Germany
Titolo Testata:
JOURNAL OF PEPTIDE RESEARCH
fascicolo: 1, volume: 58, anno: 2001,
pagine: 1 - 11
SICI:
1397-002X(200107)58:1<1:SABEOD>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHASE PEPTIDE-SYNTHESIS; FMOC-AMINO ACIDS; METARRHIZIUM-ANISOPLIAE; METARHIZIUM-ANISOPLIAE; INSECTICIDAL CYCLODEPSIPEPTIDES; DIKETOPIPERAZINE FORMATION; CLEAVAGE; RESINS; LARVAE; BOND;
Keywords:
cluster significance analysis; depsipeptide; destruxin; insecticidal activity; solid-phase synthesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Wenschuh, H Jerini Bio Tools GmbH, Rudower Chaussee 29, D-12489 Berlin, Germany Jerini Bio Tools GmbH Rudower Chaussee 29 Berlin Germany D-12489
Citazione:
T. Ast et al., "Synthesis and biological evaluation of destruxin A and related analogs", J PEPT RES, 58(1), 2001, pp. 1-11

Abstract

This report describes the development of an efficient solid-phase synthesis protocol and adaptation of reported solution phase procedures for the synthesis of the cyclic depsihexapeptide destruxin A and related analogs. The solid-phase method described is based on standard Fmoc peptide chemistry, including a new synthetic method for the assembly of the depsi bond-containing unit. In order to select analogs of destruxin A for synthesis and evaluation of insecticidal activity, the work of Hellberg et al., describing a set of Z-descriptors for amino acid side-chains comparing their physicochemical properties, was utilized. Destruxin A and 27 different analogs with structural variations in four residues were synthesized and insecticidal activity was evaluated via injections into tobacco budworm (Heliothis virescens) larvae. Several destruxin A analogs were found to be at least as potent as the native compound.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 07:29:55