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Titolo:
Neural substrates of anorexia nervosa: A behavioral challenge study with positron emission tomography
Autore:
Gordon, CM; Dougherty, DD; Fischman, AJ; Emans, SJ; Grace, E; Lamm, R; Alpert, NM; Majzoub, JA; Rauch, SL;
Indirizzi:
Childrens Hosp, Div Adolescent Young Adult Med, Boston, MA 02115 USA Childrens Hosp Boston MA USA 02115 Young Adult Med, Boston, MA 02115 USA Childrens Hosp, Div Endocrinol, Boston, MA 02115 USA Childrens Hosp Boston MA USA 02115 , Div Endocrinol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 h Med, Dept Pediat, Boston, MA 02115 USA Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 Psychiat, Boston, MA 02114 USA Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 t Radiol, Boston, MA 02114 USA
Titolo Testata:
JOURNAL OF PEDIATRICS
fascicolo: 1, volume: 139, anno: 2001,
pagine: 51 - 57
SICI:
0022-3476(200107)139:1<51:NSOANA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTTRAUMATIC-STRESS-DISORDER; CEREBRAL BLOOD-FLOW; SYMPTOM PROVOCATION; GLUCOSE-METABOLISM; EATING DISORDERS; BRAIN HYPOMETABOLISM; PET; SCHIZOPHRENIA; NEUROANATOMY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Gordon, CM Childrens Hosp, Div Adolescent Young Adult Med, 300 Longwood Ave, Boston, MA 02115 USA Childrens Hosp 300 Longwood Ave Boston MA USA 02115A 02115 USA
Citazione:
C.M. Gordon et al., "Neural substrates of anorexia nervosa: A behavioral challenge study with positron emission tomography", J PEDIAT, 139(1), 2001, pp. 51-57

Abstract

Objective: To delineate functional brain abnormalities associated with anorexia nervosa (AN). Study design: Positron emission tomographic measurements of regional cerebral blood flow (rCBF) were performed on 8 female patients with AN and 8 healthy female control subjects during exposure to 3 types of stimuli: high-calorie foods, low-calorie foods, and non-food items. Heart rate and internalstate analog scale scores were also obtained. Stereotactic transformation and statistical parametric mapping techniques were used to analyze imaging data. Results: During the high-calorie condition, control subjects reported a significant desire to eat, whereas subjects with AN reported elevated anxietyand exhibited increases in heart rate. Patients with AN had elevated bilateral medial temporal lobe rCBF compared with control subjects. Planned comparisons for group-by-condition interactions demonstrated greater activationwithin left occipital cortex and right temporo-occipital cortex for the high-calorie versus low-calorie contrast in patients with AN compared with control subjects. Conclusions: Our finding of elevated rCBF within bilateral medial temporallobes is similar to published results in patients with psychotic disordersand may be related to the body image distortion common to AN. The high-calorie food phobia exhibited by patients with AN appears to be associated with exaggerated responses in visual association cortex, as has been previously observed in studies of specific phobias.

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Documento generato il 02/04/20 alle ore 18:56:20