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Titolo:
Cortical representation of the sensory dimension of pain
Autore:
Hofbauer, RK; Rainville, P; Duncan, GH; Bushnell, MC;
Indirizzi:
McGill Univ, Dept Neurol & Neurosurg, Montreal, PQ H3A 2B4, Canada McGill Univ Montreal PQ Canada H3A 2B4 surg, Montreal, PQ H3A 2B4, Canada Montreal Neurol Inst, McConnell Brain Imaging Ctr, Montreal, PQ H3A 2B4, Canada Montreal Neurol Inst Montreal PQ Canada H3A 2B4 treal, PQ H3A 2B4, Canada Univ Iowa Hosp & Clin, Dept Neurol, Div Behav Neurol & Cognit Neurosci, Iowa City, IA 52242 USA Univ Iowa Hosp & Clin Iowa City IA USA 52242 sci, Iowa City, IA 52242 USA Univ Montreal, Fac Med Dent, Dept Stomatol, Montreal, PQ H3C 3J7, Canada Univ Montreal Montreal PQ Canada H3C 3J7 ol, Montreal, PQ H3C 3J7, Canada Univ Montreal, Ctr Rech Sci Neurol, Montreal, PQ H3C 3J7, Canada Univ Montreal Montreal PQ Canada H3C 3J7 ol, Montreal, PQ H3C 3J7, Canada McGill Univ, Dept Anesthesiol, Montreal, PQ H3A 1A1, Canada McGill Univ Montreal PQ Canada H3A 1A1 siol, Montreal, PQ H3A 1A1, Canada
Titolo Testata:
JOURNAL OF NEUROPHYSIOLOGY
fascicolo: 1, volume: 86, anno: 2001,
pagine: 402 - 411
SICI:
0022-3077(200107)86:1<402:CROTSD>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; HUMAN CINGULATE CORTEX; HUMAN CEREBRAL-CORTEX; PRIMARY SOMATOSENSORY CORTEX; NOXIOUS THERMAL-STIMULATION; HUMAN ANTERIOR CINGULATE; NOCICEPTIVE NEURONS; INSULAR CORTEX; HUMAN BRAIN; BLOOD-FLOW;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
79
Recensione:
Indirizzi per estratti:
Indirizzo: Bushnell, MC McGill Univ, Anesthesia Res Unit, 3655 Promenade Sir William Osler,Rm 1220, Montreal, PQ H3G 1Y6, Canada McGill Univ 3655 Promenade Sir William Osler,Rm 1220 Montreal PQ Canada H3G 1Y6
Citazione:
R.K. Hofbauer et al., "Cortical representation of the sensory dimension of pain", J NEUROPHYS, 86(1), 2001, pp. 402-411

Abstract

It is well accepted that pain is a multidimensional experience, but littleis known of how the brain represents these dimensions. We used positron emission tomography (PET) to indirectly measure pain-evoked cerebral activitybefore and after hypnotic suggestions were given to modulate the perceivedintensity of a painful stimulus. These techniques were similar to those ofa previous study in which we gave suggestions to modulate the perceived unpleasantness of a noxious stimulus. Ten volunteers were scanned while tonicwarm and noxious heat stimuli were presented to the hand during four experimental conditions: alert control, hypnosis control, hypnotic suggestions for increased-pain intensity and hypnotic suggestions for decreased-pain intensity. As shown in previous brain imaging studies, noxious thermal stimulipresented during the alert and hypnosis-control conditions reliably activated contralateral structures, including primary somatosensory cortex (S1), secondary somatosensory cortex (S2), anterior cingulate cortex, and insularcortex. Hypnotic modulation of the intensity of the pain sensation led to significant changes in pain-evoked activity within S1 in contrast to our previous study in which specific modulation of pain unpleasantness (affect), independent of pain intensity, produced specific changes within the ACC. This double dissociation of cortical modulation indicates a relative specialization of the sensory and the classical limbic cortical areas in the processing of the sensory and affective dimensions of pain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/05/20 alle ore 13:50:05