Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The effect of acute and chronic restraint on the central expression of prepro-neuropeptide Y mRNA in normotensive and hypertensive rats
Autore:
Sweerts, BW; Jarrott, B; Lawrence, AJ;
Indirizzi:
Monash Univ, Dept Pharmacol, Clayton, Vic 3800, Australia Monash Univ Clayton Vic Australia 3800 acol, Clayton, Vic 3800, Australia
Titolo Testata:
JOURNAL OF NEUROENDOCRINOLOGY
fascicolo: 7, volume: 13, anno: 2001,
pagine: 608 - 617
SICI:
0953-8194(200107)13:7<608:TEOAAC>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS-TRACTUS-SOLITARIUS; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; WISTAR-KYOTO RATS; MESSENGER-RIBONUCLEIC-ACID; PITUITARY-ADRENAL AXIS; EARLY GENE-EXPRESSION; OPEN-FIELD BEHAVIOR; BRAIN-STEM; ARCUATE NUCLEUS; PANCREATIC-POLYPEPTIDE;
Keywords:
stress; NPY; plasticity; CNS; spontaneously hypertensive rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Lawrence, AJ Monash Univ, Dept Pharmacol, Wellington Rd, Clayton, Vic 3800, Australia Monash Univ Wellington Rd Clayton Vic Australia 3800 ustralia
Citazione:
B.W. Sweerts et al., "The effect of acute and chronic restraint on the central expression of prepro-neuropeptide Y mRNA in normotensive and hypertensive rats", J NEUROENDO, 13(7), 2001, pp. 608-617

Abstract

Neuropeptide Y (NPY), one of the most abundant neuropeptides found in the central nervous system (CNS), has been implicated in the regulation of manyautonomic functions, including cardiovascular control and the central stress response. The present study represents a detailed investigation of the effects of acute and chronic restraint stress on the expression of the mRNA encoding the NPY precursor, prepro-NPY, in the CNS of normotensive Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR) using in situ hybridization histochemistry, Basal (unstressed) levels of prepro-NPY mRNA expression were found to be significantly increased in the hypothalamic arcuate nucleus of SHR compared to WKY rats, with similar levels of prepro-NPY mRNA expression found in the remaining central nuclei. Following exposure to both acute and chronic restraint, significant changes in prepro-NPY mRNA expression were found in a variety of central regions in both strains, including the arcuate nucleus and hippocampus (both strains), medial amygdala andcortex (WKY only), and dentate gyrus, nucleus of the solitary tract and ventrolateral medulla (SHR only). A comparison of the temporal response to restraint revealed that significant differences between strains existed in regions such as the arcuate nucleus, hippocampus and dentate gyrus, providingfurther evidence that hypertensive rats apparently have an impaired neuralstress response. The present study demonstrates that exposure to restraintresults in significant changes in prepro-NPY mRNA expression in specific nuclei of both WKY and SHR that are components of not only the central circuitry regulating the stress response, but also the neural network modulatingautonomic function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 09:58:34