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Titolo:
Axonal transport of tubulin and actin
Autore:
Galbraith, JA; Gallant, PE;
Indirizzi:
NINDS, Neurobiol Lab, NIH, Bethesda, MD 20892 USA NINDS Bethesda MD USA 20892 S, Neurobiol Lab, NIH, Bethesda, MD 20892 USA
Titolo Testata:
JOURNAL OF NEUROCYTOLOGY
fascicolo: 11-12, volume: 29, anno: 2000,
pagine: 889 - 911
SICI:
0300-4864(200011)29:11-12<889:ATOTAA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL DIABETIC NEUROPATHY; RAT SCIATIC-NERVE; CYTOSKELETAL PROTEIN-TRANSPORT; RETINAL GANGLION-CELLS; MOUSE OPTIC-NERVE; SLOW COMPONENT-B; SQUID GIANT-AXON; GROWING AXONS; FLUORESCENT MICROTUBULES; NEURONAL CENTROSOME;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
122
Recensione:
Indirizzi per estratti:
Indirizzo: Galbraith, JA NINDS, Neurobiol Lab, NIH, Bldg 36 Rm 2A-18, Bethesda, MD 20892 USA NINDS Bldg 36 Rm 2A-18 Bethesda MD USA 20892 a, MD 20892 USA
Citazione:
J.A. Galbraith e P.E. Gallant, "Axonal transport of tubulin and actin", J NEUROCYT, 29(11-12), 2000, pp. 889-911

Abstract

Axonal transport is responsible for supplying the axonal processes with proteins that are synthesized in the cell body. Among the proteins that are moved by this mechanism are tubulin and actin, two major components of the cytoskeleton. Observation of the movement of metabolically labeled tubulin and actin in-vivo has demonstrated that tubulin and actin transport are reduced in various diseases and with age, but transport is increased during axonal growth and regeneration. These metabolic studies have also raised questions about the underlying mechanisms of slow axonal transport such as: whatis the polymerization state of tubulin and actin during transport, what motors and tracks are responsible for their movement down the axon, and how are the transport motors coupled to tubulin and actin during transport ? Since experiments using metabolically labeled tubulin and actin have not effectively addressed these questions, a variety of new in-vitro fluorescent microscopy techniques have been devised to investigate these questions. These fluorescent microscopy experiments have suggested that tubulin can be transported in the unpolymerized soluble state and that such transport of soluble tubulin relies on the presence of formed microtubule tracks. It is not yet known what motor or motors are responsible for tubulin or actin transportin axons or how such a motor(s) might be coupled to such an abundant soluble cargo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/10/20 alle ore 06:33:27