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Titolo:
Alterations in brain function after loss of docosahexaenoate due to dietary restriction of n-3 fatty acids
Autore:
Salem, N; Moriguchi, T; Greiner, RS; McBride, K; Ahmad, A; Catalan, JN; Slotnick, B;
Indirizzi:
NIAAA, Sect Nutrit Neurosci, Lab Membrane Biochem & Biophys, Div Intramural Clin & Biol Res,NIH, Rockville, MD 20852 USA NIAAA Rockville MD USA 20852 Clin & Biol Res,NIH, Rockville, MD 20852 USA American Univ, Dept Psychol, Washington, DC 20016 USA American Univ Washington DC USA 20016 t Psychol, Washington, DC 20016 USA
Titolo Testata:
JOURNAL OF MOLECULAR NEUROSCIENCE
fascicolo: 2-3, volume: 16, anno: 2001,
pagine: 299 - 307
SICI:
0895-8696(200104/06)16:2-3<299:AIBFAL>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
VISUAL-ACUITY DEVELOPMENT; HEALTHY PRETERM INFANTS; ALPHA-LINOLENIC ACID; FULL-TERM INFANTS; ARACHIDONIC-ACID; RESOLUTION ACUITY; CONTROLLED TRIAL; LEARNING-TASKS; WATER-MAZE; HUMAN-MILK;
Keywords:
docosahexaenoic acid; brain development; essential fatty acids; behavior; spatial task; Morris water maze; olfactory discrimination; n-3 fatty acid deficiency; hippocampus; neuro-anatomy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Salem, N 12420 Parklawn Dr,Room 158, Rockville, MD 20852 USA 12420 Parklawn Dr,Room 158 Rockville MD USA 20852 , MD 20852 USA
Citazione:
N. Salem et al., "Alterations in brain function after loss of docosahexaenoate due to dietary restriction of n-3 fatty acids", J MOL NEURO, 16(2-3), 2001, pp. 299-307

Abstract

The concentration of the major polyunsaturated fatty acid (PUFA) in brain,docosahexaenoate, may be markedly reduced by two or more generations of dietary restriction of sources of n-3 fatty acids in the diet. Such a deficiency was induced through the feeding of safflower oil as the principal source of essential fatty acids. The reference point for this diet was an n-3 adequate diet to which alpha-linoleate and docosahexaenoate were added through the addition of a small quantity of flax seed or algael oils, respectively. The loss of brain DHA was associated with poorer performance in spatial tasks and an olfactory-cued reversal learning task. No difference could be observed in the hippocampal gross morphology. This study demonstrates the importance of providing a source of n-3 fatty acids during mammalian growth and development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:18:56