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Titolo:
Lysophosphatidylcholine as a preferred carrier form of docosahexaenoic acid to the brain
Autore:
Lagarde, M; Bernoud, N; Brossard, N; Lemaitre-Delaunay, D; Thies, F; Croset, M; Lecerf, J;
Indirizzi:
Inst Natl Sci Appl Lyon, INSERM, Biochim & Pharmacol U352, F-69621 Villeurbanne, France Inst Natl Sci Appl Lyon Villeurbanne France F-69621 Villeurbanne, France
Titolo Testata:
JOURNAL OF MOLECULAR NEUROSCIENCE
fascicolo: 2-3, volume: 16, anno: 2001,
pagine: 201 - 204
SICI:
0895-8696(200104/06)16:2-3<201:LAAPCF>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
BOVINE RETINA; HUMAN PLASMA; FATTY-ACIDS; BIOSYNTHESIS; METABOLISM; BARRIER; ALBUMIN; CELLS; RAT; DHA;
Keywords:
blood-brain barrier; fatty acid transport; lysophospholipids; omega-3 fatty acids;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Lagarde, M Inst Natl Sci Appl Lyon, INSERM, Biochim & Pharmacol U352, 20 Ave A Einstein, F-69621 Villeurbanne, France Inst Natl Sci Appl Lyon 20 Ave A Einstein Villeurbanne France F-69621
Citazione:
M. Lagarde et al., "Lysophosphatidylcholine as a preferred carrier form of docosahexaenoic acid to the brain", J MOL NEURO, 16(2-3), 2001, pp. 201-204

Abstract

The metabolic fate of docosahexaenoic acid (DHA) was evaluated from its intake as a nutrient in triglycerides and phosphatidylcholines to its uptake by target tissues, especially the brain. Several approaches were used including the kinetics and tissue distribution of ingested C-13-labeled DHA, theincorporation of radiolabeled DHA injected as its nonesterified form compared to the fatty acid esterified in lysophosphatidylcholine (lysoPC), and the capacity of the two latter forms to cross a reconstituted blood-brain barrier (BBB) consisting of cocultures of brain-capillary endothelial cells and astrocytes. The results obtained allow us to raise the hypothesis that lysoPC may represent a preferred physiological carrier of DHA to the brain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 05:00:25