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Titolo:
AA.AG@Helix.Ends: A : A and A : G base-pairs at the ends of 16 S and 23 S rRNA helices
Autore:
Elgavish, T; Cannone, JJ; Lee, JC; Harvey, SC; Gutell, RR;
Indirizzi:
Univ Texas, Inst Cellular & Mol Biol, Austin, TX 78712 USA Univ Texas Austin TX USA 78712 Cellular & Mol Biol, Austin, TX 78712 USA Univ Alabama, Dept Biochem & Mol Genet, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 Mol Genet, Birmingham, AL 35294 USA Univ Texas, Coll Pharm, Div Med Chem, Austin, TX 78712 USA Univ Texas Austin TX USA 78712 Pharm, Div Med Chem, Austin, TX 78712 USA
Titolo Testata:
JOURNAL OF MOLECULAR BIOLOGY
fascicolo: 4, volume: 310, anno: 2001,
pagine: 735 - 753
SICI:
0022-2836(20010720)310:4<735:AA:AAA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPARATIVE SEQUENCE-ANALYSIS; IRREGULAR NUCLEIC-ACIDS; RNA TERTIARY STRUCTURE; HIGHER-ORDER STRUCTURE; 30S RIBOSOMAL-SUBUNIT; MAMMARY-TUMOR VIRUS; CRYSTAL-STRUCTURE; ANGSTROM RESOLUTION; REV PEPTIDE; COAXIAL STACKING;
Keywords:
ribosomal RNA structure; comparative sequence analysis; A : A and A : G base-pairs (non-canonical pairs); structure motifs; computational biology/bioinformatics (coaxial stacking);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
74
Recensione:
Indirizzi per estratti:
Indirizzo: Gutell, RR Univ Texas, Inst Cellular & Mol Biol, 2500 Speedway, Austin, TX78712 USA Univ Texas 2500 Speedway Austin TX USA 78712 stin, TX 78712 USA
Citazione:
T. Elgavish et al., "AA.AG@Helix.Ends: A : A and A : G base-pairs at the ends of 16 S and 23 S rRNA helices", J MOL BIOL, 310(4), 2001, pp. 735-753

Abstract

This study reveals that AA and AG oppositions occur frequently at the endsof helices in RNA crystal and NMR structures in the PDB database and in the 16 S and 23 S rRNA comparative structure models, with the G usually 3 ' to the helix for the AG oppositions. In addition, these oppositions are frequently base-paired and usually in the sheared conformation, although other conformations are present in NMR and crystal structures. These A:A and A:G base-pairs are present in a variety of structural environments, including GNRA tetraloops, E and E-like loops, interfaced between two helices that arecoaxially stacked, tandem G:A base-pairs, U-turns, and adenosine platforms. Finally, given structural studies that reveal conformational rearrangements occurring in regions of the RNA with AA and AG oppositions at the ends of helices, we suggest that these conformationally unique helix extensions might be associated with functionally important structural rearrangements. (C) 2001 Academic Press.

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Documento generato il 04/04/20 alle ore 07:49:55