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Titolo:
Influence of prior meningococcal C polysaccharide vaccination on the response and generation of memory after meningococcal C conjugate vaccination inyoung children
Autore:
Borrow, R; Goldblatt, D; Andrews, N; Richmond, P; Southern, J; Miller, E;
Indirizzi:
Publ Hlth Lab Serv, Ctr Communicable Dis Surveillance, Div Immunisat, London NW9 5EQ, England Publ Hlth Lab Serv London England NW9 5EQ nisat, London NW9 5EQ, England Withington Hosp, Publ Hlth Lab Serv, Meningococcal Reference Unit, Manchester M20 8LR, Lancs, England Withington Hosp Manchester Lancs England M20 8LR M20 8LR, Lancs, England Inst Child Hlth, Immunobiol Unit, London, England Inst Child Hlth LondonEngland d Hlth, Immunobiol Unit, London, England Publ Hlth Lab Serv, Ctr Communicable Dis Surveillance, Stat Unit, London NW9 5EQ, England Publ Hlth Lab Serv London England NW9 5EQ Unit, London NW9 5EQ, England
Titolo Testata:
JOURNAL OF INFECTIOUS DISEASES
fascicolo: 3, volume: 184, anno: 2001,
pagine: 377 - 380
SICI:
0022-1899(20010801)184:3<377:IOPMCP>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNOLOGICAL MEMORY; GAMBIAN CHILDREN; GROUP-A; INDUCTION; ADULTS; HYPORESPONSIVENESS; IMMUNOGENICITY; IMMUNIZATION; VACCINES; OVERCOME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Miller, E Publ Hlth Lab Serv, Ctr Communicable Dis Surveillance, Div Immunisat, 61 Colondale Ave, London NW9 5EQ, England Publ Hlth Lab Serv 61 Colondale Ave London England NW9 5EQ land
Citazione:
R. Borrow et al., "Influence of prior meningococcal C polysaccharide vaccination on the response and generation of memory after meningococcal C conjugate vaccination inyoung children", J INFEC DIS, 184(3), 2001, pp. 377-380

Abstract

To determine whether the immunological hyporesponsiveness induced by meningococcal AC polysaccharide (MACP) vaccines can be overcome by meningococcalC conjugate (MCC) vaccine in young children, serum bactericidal antibody (SBA) serogroup C-specific IgG and IgG avidity indices were measured in young children who received MACP vaccine, followed 7 months later by MCC vaccine, and their responses were compared with those in age-matched MACP-naive control children, who received a single dose of MCC vaccine. For children <1year of age at MACP vaccination, the SBA geometric mean titer (GMT) after MCC vaccination was lower (P = .022) and proportions with SBA titers <8 (P = .0083)or <128 ( P = .0091) were higher than those in the control children. For older children, there was no difference in the SBA GMTs between the study and control groups (P > .5) or in the proportion with SBA titers <8 (P= 1.00) or <128 (P = .98). No increase in avidity occurred after MACP vaccination, whereas avidity increased significantly 1 month after MCC vaccination, with a further increase at 6 months, which indicates that the induction of immunological memory was not impaired.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:28:53