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Titolo:
Relationship between environmental fungal contamination and the incidence of invasive aspergillosis in haematology patients
Autore:
Alberti, C; Bouakline, A; Ribaud, P; Lacroix, C; Rousselot, P; Leblanc, T; Derouin, F;
Indirizzi:
Hop St Louis, Lab Parasitol Mycol, F-75475 Paris 10, France Hop St Louis Paris France 10 b Parasitol Mycol, F-75475 Paris 10, France Hop St Louis, Dept Biostat, F-75475 Paris, France Hop St Louis Paris France F-75475 s, Dept Biostat, F-75475 Paris, France Hop St Louis, Boone Marrow Transplant Unit, F-75475 Paris 10, France Hop St Louis Paris France 10 w Transplant Unit, F-75475 Paris 10, France Hop St Louis, Dept Haematol, F-75475 Paris 10, France Hop St Louis ParisFrance 10 is, Dept Haematol, F-75475 Paris 10, France
Titolo Testata:
JOURNAL OF HOSPITAL INFECTION
fascicolo: 3, volume: 48, anno: 2001,
pagine: 198 - 206
SICI:
0195-6701(200107)48:3<198:RBEFCA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; LAMINAR AIR-FLOW; NOSOCOMIAL ASPERGILLOSIS; PULMONARY ASPERGILLOSIS; MOLECULAR EPIDEMIOLOGY; HOSPITAL RENOVATION; HEMATOLOGY WARD; INFECTIONS; OUTBREAK; CONSTRUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Derouin, F Hop St Louis, Lab Parasitol Mycol, 1 Ave Claude Vellefaux, F-75475 Paris 10, France Hop St Louis 1 Ave Claude Vellefaux Paris France 10 10, France
Citazione:
C. Alberti et al., "Relationship between environmental fungal contamination and the incidence of invasive aspergillosis in haematology patients", J HOSP INF, 48(3), 2001, pp. 198-206

Abstract

Invasive aspergillosis (IA) is a major opportunistic infection in haematology patients. Spore inhalation is the usual route of Aspergillus infection,suggesting a determining role of environmental contamination by spores in the epidemiology of IA. We prospectively examined the relationship between environmental contamination by Aspergillus and other fungal species and theincidence of invasive nosocomial aspergillosis (INA) in a bone marrow transplantation unit and two haematology wards. During a four-year period, levels of air and surface fungal contamination were determined bi-monthly in patients' rooms (some equipped with HEPA filters and LAF systems), and various common sites in each ward (corridors, nursing stations, etc.). Results were compared to the incidence of INA. A total of 3100 air and 9800 surface samples were collected, and 79 cases of IA were diagnosed, of which 64 were probably or possibly INA. Patterns of fungal contamination were comparable in the three wards, with a gradient ranging from high levels in common sites to a virtual absence in rooms equipped with HEPA filters and LAF systems. Using a regression model, a significant relationship was found between theincidence of INA and the degree of fungal contamination of air and surfaces in conventional patient rooms (not equipped with HEPA) and common sites. This study shows that in a non-epidemic setting, there is a significant relationship between environmental fungal contamination in haematology wards and the incidence of INA. Our findings underline the importance of environmental surveillance and strict application of preventive measures. (C) 2001 The Hospital infection Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 04:18:05