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Titolo:
Mapping precursor movement through the postnatal thymus reveals specific microenvironments supporting defined stages of early lymphoid development
Autore:
Lind, EF; Prockop, SE; Porritt, HE; Petrie, HT;
Indirizzi:
Cornell Univ, Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA CornellUniv New York NY USA 10021 ering Canc Ctr, New York, NY 10021 USA Cornell Univ, Joan & Sanford Weill Grad Sch Med Sci, New York, NY 10021 USA Cornell Univ New York NY USA 10021 ad Sch Med Sci, New York, NY 10021 USA
Titolo Testata:
JOURNAL OF EXPERIMENTAL MEDICINE
fascicolo: 2, volume: 194, anno: 2001,
pagine: 127 - 134
SICI:
0022-1007(20010716)194:2<127:MPMTTP>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL DEVELOPMENT; CHAIN GENE REARRANGEMENT; BONE-MARROW CELLS; IMMATURE THYMOCYTES; TRANSIENT EXPRESSION; EPITHELIAL-CELLS; MOUSE THYMUS; STEM-CELLS; ALPHA-BETA; RECEPTOR;
Keywords:
thymus; stromal cells; cell differentiation; cell movement; histology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Petrie, HT Cornell Univ, Mem Sloan Kettering Canc Ctr, Box 341,1275 York Ave, New York, NY 10021 USA Cornell Univ Box 341,1275 York Ave New York NY USA 10021 21 USA
Citazione:
E.F. Lind et al., "Mapping precursor movement through the postnatal thymus reveals specific microenvironments supporting defined stages of early lymphoid development", J EXP MED, 194(2), 2001, pp. 127-134

Abstract

Cellular differentiation is a complex process involving integrated signalsfor lineage specification, proliferation, endowment of functional capacity, and survival or cell death. During embryogenesis, spatially discrete environments regulating these processes are established during the growth of tissue mass, a process that also results in temporal separation of developmental events. In tissues that undergo steady-state postnatal differentiation,another means for inducing spatial and temporal separation of developmental cues must be established. Here we show that in the postnatal thymus, thisis achieved by inducing blood-borne precursors to enter the organ in a narrow region of the perimedullary cortex, followed by outward migration across the cortex before accumulation in the subcapsular zone. Notably, blood precursors do not transmigrate the cortex in an undifferentiated state, but rather undergo progressive developmental changes during this process, such that defined precursor stages appear in distinct cortical regions. Identification of these cortical regions, together with existing knowledge regardingthe genetic potential of the corresponding lymphoid precursors, sets operational boundaries for stromal environments that are likely to induce these differentiative events. We conclude that active cell migration between morphologically similar but functionally distinct stromal regions is an integral component regulating differentiation and homeostasis in the steady-state thymus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 01:22:26