Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Parallel cortico-basal ganglia mechanisms for acquisition and execution ofvisuomotor sequences - A computational approach
Autore:
Nakahara, H; Doya, K; Hikosaka, O;
Indirizzi:
RIKEN, Brain Sci Inst, Lab Math Neurosci, Wako, Saitama 3510198, Japan RIKEN Wako Saitama Japan 3510198 h Neurosci, Wako, Saitama 3510198, Japan Juntendo Univ, Tokyo, Japan Juntendo Univ Tokyo JapanJuntendo Univ, Tokyo, Japan
Titolo Testata:
JOURNAL OF COGNITIVE NEUROSCIENCE
fascicolo: 5, volume: 13, anno: 2001,
pagine: 626 - 647
SICI:
0898-929X(20010701)13:5<626:PCGMFA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUPPLEMENTARY MOTOR AREA; POSITRON EMISSION TOMOGRAPHY; POSTERIOR PARIETAL CORTEX; NEURONAL-ACTIVITY; SEQUENTIAL MOVEMENTS; WORKING-MEMORY; RHESUS-MONKEY; FUNCTIONAL-ANATOMY; PREMOTOR CORTEX; CEREBRAL-CORTEX;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
115
Recensione:
Indirizzi per estratti:
Indirizzo: Nakahara, H RIKEN, Brain Sci Inst, Lab Math Neurosci, 2-1 Hirosawa, Wako, Saitama 3510198, Japan RIKEN 2-1 Hirosawa Wako Saitama Japan 3510198 a 3510198, Japan
Citazione:
H. Nakahara et al., "Parallel cortico-basal ganglia mechanisms for acquisition and execution ofvisuomotor sequences - A computational approach", J COGN NEUR, 13(5), 2001, pp. 626-647

Abstract

Experimental studies have suggested that many brain areas, including the basal ganglia (BG), contribute to procedural learning. Focusing on the basalganglia-thalamocortical (BG-TC) system, we propose a computational model to explain how different brain areas work together in procedural learning. The BG-TC system is composed of multiple separate loop circuits. According to our model, two separate BG-TC loops learn a visuomotor sequence concurrently but using different coordinates, one visual, and the other motor. The visual loop includes the dorsolateral prefrontal (DLPF) cortex and the anterior part of the BG, while the motor loop includes the supplementary motor area (SMA) and the posterior BG. The concurrent learning in these loops is based on reinforcement signals carried by dopaminergic (DA) neurons that project divergently to the anterior ("visual") anti posterior ("motor") parts of the striatum. It is expected, however, that the visual loop learns a sequence faster than the motor loop due to their different coordinates. The difference in learning speed may lead to inconsistent outputs from the visualand motor loops, and this problem is solved by a. mechanism called a "coordinator," which adjusts the contribution of the visual and motor loops to afinal motor output. The coordinator is assumed to be in the presupplementary motor area (pre-SMA). We hypothesize that the visual and motor loops, with the help of the coordinator, achieve both the quick acquisition of novelsequences and the robust execution of well-learned sequences. A computational model based on the hypothesis is examined in a series of computer simulations, referring to the results of the 2 x 5 cask experiments that have been used on both monkeys and humans. We found that the dual mechanism with the coordinator was superior to the single (visual or motor) mechanism. The model replicated the following essential features of the experimental results: (1) the time course of learning, (2) the effect of opposite hand use, (3) the effect of sequence reversal, and (4) the effects of localized brain inactivations. Our model may account for a common feature of procedural learning: A spatial sequence of discrete actions (subserved by the visual loop) is gradually replaced by a robust motor skill (subserved by the motor loop).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:21:13