Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Monitoring response during a randomised controlled trial of escalating interferon dose for chronic hepatitis C infection: predictive value of quantitative and qualitative HCV RNA assays
Autore:
Schinkel, J; Kroes, ACM; Wagtmans, MJ; Lamers, CBHW; van Hoek, B;
Indirizzi:
Leiden Univ, Med Ctr, Dept Med Microbiol, NL-2300 RC Leiden, Netherlands Leiden Univ Leiden Netherlands NL-2300 RC NL-2300 RC Leiden, Netherlands Flevoziekenhuis, Almere, Netherlands Flevoziekenhuis Almere NetherlandsFlevoziekenhuis, Almere, Netherlands Leiden Univ, Med Ctr, Dept Gastroenterol & Hepatol, NL-2300 RC Leiden, Netherlands Leiden Univ Leiden Netherlands NL-2300 RC NL-2300 RC Leiden, Netherlands
Titolo Testata:
JOURNAL OF CLINICAL VIROLOGY
fascicolo: 1, volume: 22, anno: 2001,
pagine: 61 - 71
SICI:
1386-6532(200108)22:1<61:MRDARC>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLUS RIBAVIRIN; VIRUS-RNA; THERAPY; COMBINATION; ALPHA; QUANTIFICATION; UTILITY; PLACEBO; ALFA;
Keywords:
interferon-alpha; HCV RNA; dose escalation; hepatitis C; viral load; therapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Schinkel, J Leiden Univ, Med Ctr, Dept Med Microbiol, POB 9600, NL-2300 RCLeiden, Netherlands Leiden Univ POB 9600 Leiden Netherlands NL-2300 RC etherlands
Citazione:
J. Schinkel et al., "Monitoring response during a randomised controlled trial of escalating interferon dose for chronic hepatitis C infection: predictive value of quantitative and qualitative HCV RNA assays", J CLIN VIRO, 22(1), 2001, pp. 61-71

Abstract

Background: In chronic hepatitis C infection, raising the interferon dose in initial non-responders may increase the generally poor sustained response rates. Monitoring virological response is essential in this kind of individual patient based approach. Quantitative HCV RNA assays are increasingly used for this purpose. However, their additional value as compared to strictly qualitative HCV RNA assays should be evaluated before they are implemented as a routine measurement, since these assays are more expensive and time consuming than qualitative assays. Objectives: Goals of this study were (1) to test the hypothesis that increasing interferon dose in initial non-responders results in permanent viral clearance in more patients and (2) evaluation of the predictive value of quantitative versus qualitative HCV RNA assays before and during: treatment. Study design: 63 patients were treated in a randomised controlled trial of escalating interferon dose. In the standard treatment group patients received 6 MU alpha-2a thrice weekly for 3 months followed by 3 MU thrice weekly for 3 months. In the experimental groupinterferon dose was escalated at 6 weeks to 9 MU if I-ICV RNA was still detectable at 4 weeks. Predictors of response were analyzed at various time points before and during treatment and the predictive value of quantitative HCV RNA measurements was compared to that of qualitative HCV RNA assays. Results: No significant difference in sustained response rate was found between the treatment groups at the end of follow-up. At baseline, the strongestindependent predictor for a sustained response was a viral load level below 10(6) copies/ml and age younger than 40 years. During treatment a negative HCV RNA status at week 4 was the strongest predictor of a sustained response. Viral load levels during treatment did not independently predict a sustained response. Conclusions: While on treatment, qualitative HCV RNA assays should be used to monitor response. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 11:40:00