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Titolo:
Novel antipsychotics and severe hyperlipidemia
Autore:
Meyer, JM;
Indirizzi:
Oregon State Hosp, Adult Treatment Serv, Salem, OR USA Oregon State Hosp Salem OR USA Hosp, Adult Treatment Serv, Salem, OR USA Oregon Hlth Sci Univ, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 i Univ, Portland, OR 97201 USA
Titolo Testata:
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
fascicolo: 4, volume: 21, anno: 2001,
pagine: 369 - 374
SICI:
0271-0749(200108)21:4<369:NAASH>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
SERUM TRIGLYCERIDE LEVELS; SCHIZOPHRENIC-PATIENTS; DIABETES-MELLITUS; CARDIOVASCULAR-DISEASE; WEIGHT-GAIN; BODY-WEIGHT; OBESE GENE; CLOZAPINE; LIPIDS; HYPERTRIGLYCERIDEMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Meyer, JM 300 NW 8th Ave,Suite 606, Portland, OR 97209 USA 300 NW 8th Ave,Suite 606 Portland OR USA 97209 nd, OR 97209 USA
Citazione:
J.M. Meyer, "Novel antipsychotics and severe hyperlipidemia", J CL PSYCH, 21(4), 2001, pp. 369-374

Abstract

Newer atypical antipsychotics demonstrate superior effectiveness, with a diminished incidence of extrapyramidal side effects compared with older typical antipsychotics, but they have been associated with the development of obesity and new-onset diabetes. A small number of reports documenting modesthypertriglyceridemia related to newer antipsychotics have implicated fluperlapine, clozapine, and, most recently, olanzapine. This study summarizes the results of 14 cases of severe hypertriglyceridemia (> 600 mg/dL) associated with olanzapine and quetiapine therapy occurring among inpatients at Oregon State Hospital, including 7 patients whose serum triglyceride levels exceeded 1,000 mg/dL. Four of these patients also developed new-onset diabetes. Nine cases occurred during the first 8 months of treatment, with three cases identified within 3 months of commencing olanzapine or quetiapine therapy. Weight gain in olanzapine and quetiapine groups was modest (12.3 Ib and 8.5 Ib, respectively) and did not correlate with the severity of hypertriglyceridemia. Biochemical causes for severe hypertriglyceridemia associated with novel antipsychotics are unclear, but clinical monitoring of serum Lipids must be added to the concerns about the metabolic consequences of therapy with certain newer antipsychotic agents.

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Documento generato il 08/12/19 alle ore 11:50:24