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Titolo:
Subantimicrobial dose doxycycline as an adjunct to scaling and root planing: post-treatment effects
Autore:
Caton, JG; Ciancio, SG; Blieden, TM; Bradshaw, M; Crout, RJ; Hefti, AF; Massaro, JM; Polson, AM; Thomas, J; Walker, C;
Indirizzi:
Univ Rochester, Eastman Dent Ctr, Rochester, NY 14620 USA Univ Rochester Rochester NY USA 14620 n Dent Ctr, Rochester, NY 14620 USA SUNY Buffalo, Dept Periodont, Buffalo, NY 14260 USA SUNY Buffalo Buffalo NY USA 14260 , Dept Periodont, Buffalo, NY 14260 USA Icon Clin Res, Norristown, PA USA Icon Clin Res Norristown PA USAIcon Clin Res, Norristown, PA USA W Virginia Univ, Med Ctr, Off Dent Res, Morgantown, WV 26506 USA W Virginia Univ Morgantown WV USA 26506 ent Res, Morgantown, WV 26506 USA Ohio State Univ, Coll Dent, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 , Coll Dent, Columbus, OH 43210 USA Boston Univ, Sch Publ Hlth, Boston, MA USA Boston Univ Boston MA USABoston Univ, Sch Publ Hlth, Boston, MA USA Univ Penn, Dept Periodont, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Periodont, Philadelphia, PA 19104 USA W Virginia Univ, Dept Pathol, Morgantown, WV USA W Virginia Univ Morgantown WV USA Univ, Dept Pathol, Morgantown, WV USA Univ Florida, Periodontal Dis Res Ctr, Gainesville, FL USA Univ Florida Gainesville FL USA odontal Dis Res Ctr, Gainesville, FL USA
Titolo Testata:
JOURNAL OF CLINICAL PERIODONTOLOGY
fascicolo: 8, volume: 28, anno: 2001,
pagine: 782 - 789
SICI:
0303-6979(200108)28:8<782:SDDAAA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
MATRIX METALLOPROTEINASES; PERIODONTAL-DISEASES; TETRACYCLINE; COLLAGENASES; GINGIVA; BONE;
Keywords:
doxycycline; subantimicrobial; matrix metalloproteinases; periodontitis; scaling and root planing; post-treatment;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Caton, JG Univ Rochester, Eastman Dent Ctr, 625 Elmwood Ave, Rochester, NY14620 USA Univ Rochester 625 Elmwood Ave Rochester NY USA 14620 14620 USA
Citazione:
J.G. Caton et al., "Subantimicrobial dose doxycycline as an adjunct to scaling and root planing: post-treatment effects", J CLIN PER, 28(8), 2001, pp. 782-789

Abstract

Background/objective: Subantimicrobial dose doxycycline (SDD 20 mg bid) plus scaling and root planing (SRP) significantly improved clinical attachment level (CAL) and reduced probing depth (PD) compared with placebo plus SRPin a double-blind, placebo-controlled, multicenter study of patients with adult periodontitis (AP). In a study conducted as a follow-up, the post-treatment effects of SDD were assessed in patients who completed the SRP study. Methods: The SRP study was a 9-month, active-treatment study and the followup was a 3-month, no-treatment study. In the SRP study, tooth sites in qualifying quadrants were scaled and root planed and patients were randomized to receive twice daily SDD 20 mg or placebo. In the follow-up, patients received no study drug; investigators and patients remained blinded to the previous treatment group assignments. Efficacy measures included the change inCAL and PD from baseline values determined at the start of the SRP study in tooth sites stratified by baseline PD (i.e., 0-3 mm, 4-6 mm, greater thanor equal to7 mm). Safety was evaluated using adverse event data and the results of clinical laboratory tests, oral pathology examinations, and microbiological assessments. Results: Within each disease stratum, the incremental improvements in PD and CAL demonstrated in the SDD group over 9 months of active treatment weremaintained through 3 additional months of no treatment. Treatment cessation did not result in an accelerated regression of periodontal health. No differences in the incidence of adverse events (including those related to infection) or laboratory or microbiological parameters were noted between the SDD group and the placebo group. Conclusions: The administration of SDD 20 mg bid for a period of up to 9 months is not associated with rebound effects or delayed or negative aftereffects for a 3-month period after cessation of therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 02:32:43