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Titolo:
FGF receptor signalling is required to maintain neural progenitors during Hensen's node progression
Autore:
Mathis, L; Kulesa, PM; Fraser, SE;
Indirizzi:
CALTECH, Biol Imaging Ctr, Beckman Inst 139 74, Pasadena, CA 91125 USA CALTECH Pasadena CA USA 91125 Beckman Inst 139 74, Pasadena, CA 91125 USA
Titolo Testata:
NATURE CELL BIOLOGY
fascicolo: 6, volume: 3, anno: 2001,
pagine: 559 - 566
SICI:
1465-7392(200106)3:6<559:FRSIRT>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; FIBROBLAST GROWTH-FACTOR; CHICK-EMBRYO; FATE MAP; ANTEROPOSTERIOR AXIS; CELL REARRANGEMENT; XENOPUS EMBRYOS; MOUSE EMBRYO; STEM-CELLS; INDUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Fraser, SE CALTECH, Biol Imaging Ctr, Beckman Inst 139 74, Pasadena, CA 91125 USA CALTECH Pasadena CA USA 91125 t 139 74, Pasadena, CA 91125 USA
Citazione:
L. Mathis et al., "FGF receptor signalling is required to maintain neural progenitors during Hensen's node progression", NAT CELL BI, 3(6), 2001, pp. 559-566

Abstract

Previous analyses of labelled clones of cells within the developing nervous system of the mouse have indicated that descendants are initially dispersed rostrocaudally followed by more local proliferation, which is consistentwith the progressing node's contributing descendants from a resident population of progenitor cells as it advances caudally. Here we electroporated an expression vector encoding green fluorescent protein into the chicken embryo near Hensen's node to test and confirm the pattern inferred in the mouse. This provides a model in which a proliferative stem zone is maintained in the node by a localized signal; those cells that are displaced out of thestem zone go on to contribute to the growing axis. To test whether fibroblast growth factor (FGF) signalling could be involved in the maintenance of the stem zone, we co-electroporated a dominant-negative FGF receptor with alineage marker, and found that it markedly alters the elongation of the spinal cord primordium. The results indicate that FGF receptor signalling promotes the continuous development of the posterior nervous system by maintaining presumptive neural progenitors in the region near Hensen's node. This offers a potential explanation for the mixed findings on FGF in the growth and patterning of the embryonic axis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 02:25:37