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Titolo:
Apaf-1 is a transcriptional target for E2F and p53
Autore:
Moroni, MC; Hickman, ES; Denchi, EL; Caprara, G; Colli, E; Cecconi, F; Muller, H; Helin, K;
Indirizzi:
European Inst Oncol, Dept Expt Oncol, I-20141 Milan, Italy European Inst Oncol Milan Italy I-20141 Expt Oncol, I-20141 Milan, Italy Max Planck Inst Biophys Chem, Dept Mol Cell Biol, D-37077 Gottingen, Germany Max Planck Inst Biophys Chem Gottingen Germany D-37077 ottingen, Germany
Titolo Testata:
NATURE CELL BIOLOGY
fascicolo: 6, volume: 3, anno: 2001,
pagine: 552 - 558
SICI:
1465-7392(200106)3:6<552:AIATTF>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
S-PHASE ENTRY; CELL-DEATH; RETINOBLASTOMA PROTEIN; DNA-SYNTHESIS; APOPTOSIS; INHIBITION; CASPASE-9; PATHWAYS; HOMOLOG; P73;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Helin, K European Inst Oncol, Dept Expt Oncol, Via Ripamonti 435, I-20141 Milan, Italy European Inst Oncol Via Ripamonti 435 Milan Italy I-20141 Italy
Citazione:
M.C. Moroni et al., "Apaf-1 is a transcriptional target for E2F and p53", NAT CELL BI, 3(6), 2001, pp. 552-558

Abstract

Loss of function of the retinoblastoma protein, pRB, leads to lack of differentiation, hyperproliferation and apoptosis. Inactivation of pRB results in deregulated E2F activity, which in turn induces entry to S-phase and apoptosis. Induction of apoptosis by either the loss of pRB or the deregulation of E2F activity occurs via both p53-dependent and p53-independent mechanisms. The mechanism by which E2F induces apoptosis is still unclear. Here weshow that E2F1 directly regulates the expression of Apaf-1, the gene for apoptosis protease-activating factor 1. These results provide a direct link between the deregulation of the pRB pathway and apoptosis. Furthermore, because the pRB pathway is functionally inactivated in most cancers, the identification of Apaf-1 as a transcriptional target for E2F might explain the increased sensitivity of tumour cells to chemotherapy. We also show that, independently of the pRB pathway, Apaf-1 is a direct transcriptional target of p53, suggesting that p53 might sensitize cells to apoptosis by increasingApaf-1 levels.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 08:18:35