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Titolo:
Single neurons in prefrontal cortex encode abstract rules
Autore:
Wallis, JD; Anderson, KC; Miller, EK;
Indirizzi:
MIT, Ctr Learning & Memory, RIKEN, Neurosci Res Ctr, Cambridge, MA 02139 USA MIT Cambridge MA USA 02139 KEN, Neurosci Res Ctr, Cambridge, MA 02139 USA MIT, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA MIT Cambridge MA USA 02139 pt Brain & Cognit Sci, Cambridge, MA 02139 USA
Titolo Testata:
NATURE
fascicolo: 6840, volume: 411, anno: 2001,
pagine: 953 - 956
SICI:
0028-0836(20010621)411:6840<953:SNIPCE>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORBITOFRONTAL CORTEX; NEURAL ACTIVITY; FRONTAL-CORTEX; WORKING-MEMORY; UNIT-ACTIVITY; PRIMATE; REWARD; MACAQUE; MONKEY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Miller, EK MIT, Ctr Learning & Memory, RIKEN, Neurosci Res Ctr, Cambridge,MA 02139 USA MIT Cambridge MA USA 02139 ci Res Ctr, Cambridge, MA 02139 USA
Citazione:
J.D. Wallis et al., "Single neurons in prefrontal cortex encode abstract rules", NATURE, 411(6840), 2001, pp. 953-956

Abstract

The ability to abstract principles or rules from direct experience allows behaviour to extend beyond specific circumstances to general situations. For example, we learn the 'rules' for restaurant dining from specific experiences and can then apply them in new restaurants. The use of such rules is thought to depend on the prefrontal cortex (PFC) because its damage often results in difficulty in following rules(1). Here we explore its neural basisby recording from single neurons in the PFC of monkeys trained to use two abstract rules. They were required to indicate whether two successively presented pictures were the same or different depending on which rule was currently in effect. The monkeys performed this task with new pictures, thus showing that they had learned two general principles that could be applied tostimuli that they had not yet experienced. The most prevalent neuronal activity observed in the PFC reflected the coding of these abstract rules.

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Documento generato il 24/01/20 alle ore 12:28:27