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Titolo:
The relation between objective and subjective impairment in cognitive function among multiple sclerosis patients - the role of depression
Autore:
Maor, Y; Olmer, L; Mozes, B;
Indirizzi:
Tel Aviv Univ, Gertner Inst Epidemiol & Hlth Policy Res, Ctr Study Clin Reasoning, Chaim Sheba Med Ctr, IL-52621 Tel Hashomer, Israel Tel Aviv Univ Tel Hashomer Israel IL-52621 IL-52621 Tel Hashomer, Israel
Titolo Testata:
MULTIPLE SCLEROSIS
fascicolo: 2, volume: 7, anno: 2001,
pagine: 131 - 135
SICI:
1352-4585(200104)7:2<131:TRBOAS>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARTERY BYPASS-SURGERY; PERFORMANCE; DYSFUNCTION; COMPLAINTS; EPILEPSY; ADULTS;
Keywords:
cognitive assessment; cognitive functioning; depression; multiple sclerosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Maor, Y Tel Aviv Univ, Gertner Inst Epidemiol & Hlth Policy Res, Ctr StudyClin Reasoning, Chaim Sheba Med Ctr, IL-52621 Tel Hashomer, Israel Tel Aviv Univ Tel Hashomer Israel IL-52621 Tel Hashomer, Israel
Citazione:
Y. Maor et al., "The relation between objective and subjective impairment in cognitive function among multiple sclerosis patients - the role of depression", MULT SCLER, 7(2), 2001, pp. 131-135

Abstract

Objective: To evaluate the relations between perceived cognitive function and objective cognitive deficit and to assess variables affecting perceivedcognitive function among multiple sclerosis (MS) patients. Methods: A cross sectional study of patients with MS. All patients were interviewed and the Expanded Disability Status Scale (EDSS) score was determined. The dependent variables were four items assessing perceived concentration and thinking, attention, memory, and whether others have noticed memory or concentration problems. The explanatory variables were age, sex, duration of disease, number of relapses in the last 2 years, EDSS score, depressive symptoms score (CES-D) and the domains of the Neurobehavioral Cognitive Status Examination (NCSE) assessing cognitive performance. Bivariate and then multivariate analysis were performed. Results: One hundred and sixty-one MS patients were included. Mean age was 44.2 years (s.d. 11.3 years), mean EDSS score was 4.86 (s.d. 1.93). Seventy-two per cent of the patients had objective cognitive impairment and 51% reported decreased perceived cognitive function. In all models assessing perceived cognitive function rye could explain only a small part of the variance (R-2 ranged between 18-26%). In ah these models depressive symptoms explained the highest portion of the variance (partial R-2 ranging between 13-26%). The only domain of the NCSE that entered some of the models was calculation (partial R2 ranging between 3-7%). Conclusions: These findings emphasize the gap between objective and subjective assessment of cognitive function and the high correlation between perceived cognitive deficit and depressive symptoms.

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Documento generato il 26/01/20 alle ore 10:48:54