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Titolo:
Sodium fusidate (fusidin) ameliorates the course of monophasic experimental allergic encephalomyelitis in the Lewis rat
Autore:
Di Marco, R; Puglisi, G; Papaccio, G; Nicoletti, A; Patti, F; Reggio, A; Bendtzen, K; Nicoletti, F;
Indirizzi:
Univ Milan, Bicocca, Dept Clin Med Prevent & Biotechnol Hlth, Milan, ItalyUniv Milan Milan Italy Clin Med Prevent & Biotechnol Hlth, Milan, Italy Copenhagen Univ Hosp, Rigshosp, Inst Inflammat Res, Copenhagen, Denmark Copenhagen Univ Hosp Copenhagen Denmark lammat Res, Copenhagen, Denmark Univ Catania, Inst Neurol, Catania, Italy Univ Catania Catania ItalyUniv Catania, Inst Neurol, Catania, Italy Univ Naples 2, Sch Med, Inst Histol & Embryol, Naples, Italy Univ Naples 2 Naples Italy ch Med, Inst Histol & Embryol, Naples, Italy Univ Catania, Dept Microbiol & Gynaecol Sci, Catania, Italy Univ Catania Catania Italy ept Microbiol & Gynaecol Sci, Catania, Italy
Titolo Testata:
MULTIPLE SCLEROSIS
fascicolo: 2, volume: 7, anno: 2001,
pagine: 101 - 104
SICI:
1352-4585(200104)7:2<101:SF(ATC>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; DEPENDENT DIABETES-MELLITUS; PRONE BB RATS; MULTIPLE-SCLEROSIS; INTERFERON-GAMMA; MESSENGER-RNA; ANIMAL-MODELS; ACID; INTERLEUKIN-12; SUPPRESSION;
Keywords:
experimental allergic encephalomyelitis; immunotherapy; multiple sclerosis; sodium fusidate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Nicoletti, F Via Luigi Sturzo 3, I-95021 Catania, Italy Via Luigi Sturzo 3 Catania Italy I-95021 021 Catania, Italy
Citazione:
R. Di Marco et al., "Sodium fusidate (fusidin) ameliorates the course of monophasic experimental allergic encephalomyelitis in the Lewis rat", MULT SCLER, 7(2), 2001, pp. 101-104

Abstract

We have evaluated the effect of the immunosuppressant sodium fusidate (fusidin) on the course of acute monophasic experimental encephalomyelitis (EAE) in mole Lewis rots. Prophylactic treatment with Fusidin, 80 or 120 mg/kg bd wt, markedly ameliorated the course of the disease in rots immunized with myelin basic proteins in complete Freund's adjuvant, entailing delayed onset of symptoms, lower clinical scores and more rapid recovery than PBS-treated control rots. The Fusidin-treated, immunized rots exhibited milder mononuclear cell infiltration of brains and spinel cords then control animals. These data provide further evidence for the anti-inflammatory effect of fusidin and suggest that this drug may be valuable for the treatment of humanmultiple sclerosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 18:15:20