Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Quantitative contrast-enhanced magnetic resonance imaging to evaluate blood-brain barrier integrity in multiple sclerosis: a preliminary study
Autore:
Silver, NC; Tofts, PS; Symms, MR; Barker, GJ; Thompson, AJ; Miller, DH;
Indirizzi:
Univ Coll London, Inst Neurol, NMR Res Unit, London WC1N 3BG, England UnivColl London London England WC1N 3BG Unit, London WC1N 3BG, England
Titolo Testata:
MULTIPLE SCLEROSIS
fascicolo: 2, volume: 7, anno: 2001,
pagine: 75 - 82
SICI:
1352-4585(200104)7:2<75:QCMRIT>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
APPEARING WHITE-MATTER; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; DOSE GADOLINIUM-DTPA; DISEASE-ACTIVITY; TREATMENT TRIALS; MRI; LESIONS; SENSITIVITY; DISABILITY; IMPAIRMENT;
Keywords:
multiple sclerosis; magnetic resonance imaging; gadolinium; blood-brain barrier; lesion; normal-appearing white matter;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Miller, DH Univ Coll London, Inst Neurol, NMR Res Unit, Queen Sq, London WC1N 3BG, England Univ Coll London Queen Sq London England WC1N 3BG 3BG, England
Citazione:
N.C. Silver et al., "Quantitative contrast-enhanced magnetic resonance imaging to evaluate blood-brain barrier integrity in multiple sclerosis: a preliminary study", MULT SCLER, 7(2), 2001, pp. 75-82

Abstract

Gadolinium enhanced magnetic resonance imaging detects focal blood-brain barrier breakdown in new inflammatory multiple sclerosis lesions, but such lesions do not correlate with disease progression. To explore whether the latter might relate to subtle but widespread blood-brain barrier (BBB) breakdown with low grade inflammation mediating tissue damage, quantitative techniques were used to detect subtle gadolinium enhancement within otherwise normal-appearing white matter and within lesions not showing visible enhancement TI-weighted imaging was performed prior to and at 5, 20 and 40 min following injection of 0.3 mmol/kg gadopentate dimeglumine in 33 patients with multiple sclerosis and five healthy control subjects. In healthy controls, a significant increase in white matter signal 5 min following contrast injection was observed (1.8%, P < 0.0005); the signal returned to baseline values by 20 min. In multiple sclerosis patients, a non-significant trend was noted for signal to remain elevated in normal-appearing white matter at the 20 and 40 min post-contrast time points; this was most apparent in primary progressive multiple sclerosis. Significant increases in signal intensity were noted at all time points post contrast in apparent non-enhancing lesions. The transient post contrast signal increase in controls is likely due tointravascular gadopentate dimeglumine. The persistent increases in signal intensity in non-enhancing lesions suggest more widespread abnormalities inBBB than is visually apparent but substantiation of BBB leakage in normal appearing white matter will require further study using more sensitive methods.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 18:47:10