Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Treatment with interferon-alpha (IFN alpha) of hepatitis C patients induces lower serum dipeptidyl peptidase IV activity, which is related to IFN alpha-induced depressive and anxiety symptoms and immune activation
Autore:
Maes, M; Bonaccorso, S; Marino, V; Puzella, A; Pasquini, M; Biondi, M; Artini, M; Almerighi, C; Meltzer, H;
Indirizzi:
Univ Hosp Maastricht, Dept Psychiat, Maastricht, Netherlands Univ Hosp Maastricht Maastricht Netherlands at, Maastricht, Netherlands Vanderbilt Univ, Dept Psychiat, Nashville, TN USA Vanderbilt Univ Nashville TN USA Univ, Dept Psychiat, Nashville, TN USA Univ La Sapienza, Hosp Psychiat, Rome, Italy Univ La Sapienza Rome Italy niv La Sapienza, Hosp Psychiat, Rome, Italy Univ La Sapienza, Med Clin 1, Dept Hepatol, Rome, Italy Univ La Sapienza Rome Italy enza, Med Clin 1, Dept Hepatol, Rome, Italy
Titolo Testata:
MOLECULAR PSYCHIATRY
fascicolo: 4, volume: 6, anno: 2001,
pagine: 475 - 480
SICI:
1359-4184(200107)6:4<475:TWI(AO>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUBULAR EPITHELIAL-CELLS; MAJOR DEPRESSION; AMINOPEPTIDASE N/CD13; CARCINOMA-CELLS; GAMMA; INTERLEUKIN-6; EXPRESSION; CYTOKINES; IV/CD26; CAMP;
Keywords:
interferon; cytokines; depression; anxiety; peptidases; dipeptidyl peptidase IV;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Maes, M Univ Hosp Maastricht, Chairman Dept Psychiat & Neuropsychol, Postbus 5800,NL-6202 AZ Maastricht, Netherlands Univ Hosp Maastricht Postbus 5800 Maastricht Netherlands NL-6202 AZ
Citazione:
M. Maes et al., "Treatment with interferon-alpha (IFN alpha) of hepatitis C patients induces lower serum dipeptidyl peptidase IV activity, which is related to IFN alpha-induced depressive and anxiety symptoms and immune activation", MOL PSYCHI, 6(4), 2001, pp. 475-480

Abstract

We have shown that treatment with interleukin-2 (IL-2) or interferon-alpha(IFN alpha) may induce depressive symptoms and activation of the cytokine network and that IL-2 treatment may diminish serum dipeptidyl pepdidase IV (DPP IV) activity.(1-3) DPP IV (EC 3.4.14.5) is a membrane bound serine protease which catalyzes the cleavage of some cytokines and neuroactive peptides which modulate T cell activity.(4) The aims of the present study were toexamine the effects of IFN alpha -based immunotherapy on serum DPP IV activity in relation to induction of the inflammatory response system. In 18 patients with chronic active hepatitis C, we determined the Montgomery and Asberg Rating Scale (MADRS),(5) the Hamilton Anxiety Rating Scale (HAM-A),(6)serum DPP IV activity, the kynurenine/tryptophan (WT) quotient, which is an indicator of cytokine (in particular IFN)-induced catabolism of tryptophan,(7) and serum interleukin-8 (IL-8) before starting therapy and 2, 4, 16 and 24 weeks after immunotherapy with IFN alpha. IFN alpha -immunotherapy significantly suppressed serum DPP IV 2-4 weeks and 16-24 weeks after starting IFN alpha -based immunotherapy, The reduction in serum DPP IV activity was more pronounced 16-24 weeks after starting immunotherapy than after 2-4 weeks. The IFN alpha -induced suppression of serum DPP IV activity was significantly correlated to IFN alpha -induced increases in the MADRS and HAM-A and increases in the K/T quotient and serum IL-8. In conclusion, long-term immunotherapy with IFNa suppresses serum DPP IV activity and the immunotherapy-induced changes in DPP IV are related to increases in severity of depression, anxiety and activation of the inflammatory response system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 02:27:32