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Titolo:
Attention deficit hyperactivity disorder (ADHD) and the dopamine D4 receptor gene: evidence of association but no linkage in a UK sample
Autore:
Mill, J; Curran, S; Kent, L; Richards, S; Gould, A; Virdee, V; Huckett, L; Sharp, J; Batten, C; Fernando, S; Simanoff, E; Thompson, M; Zhao, J; Sham, P; Taylor, E; Asherson, P;
Indirizzi:
Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, London SE5 8AF, England Inst Psychiat London England SE5 8AF at Res Ctr, London SE5 8AF, England Univ Birmingham, Dept Psychiat, Birmingham B15 2TT, W Midlands, England Univ Birmingham Birmingham W Midlands England B15 2TT W Midlands, England Ashurst Hosp, Child & Family Hlth Ctr, Southampton SO40 7AR, Hants, England Ashurst Hosp Southampton Hants England SO40 7AR SO40 7AR, Hants, England GKT Med Sch, Dept Child & Adolescent Psychiat, London SE1 3SS, England GKTMed Sch London England SE1 3SS ent Psychiat, London SE1 3SS, England
Titolo Testata:
MOLECULAR PSYCHIATRY
fascicolo: 4, volume: 6, anno: 2001,
pagine: 440 - 444
SICI:
1359-4184(200107)6:4<440:ADHD(A>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
III REPEAT POLYMORPHISM; DRD4 GENE; VARIANTS; QUESTIONNAIRE; CHILD;
Keywords:
ADHD; DRD4; genetic association;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Asherson, P Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, De Crespigny Pk, London SE5 8AF, England Inst Psychiat De Crespigny Pk London England SE5 8AF England
Citazione:
J. Mill et al., "Attention deficit hyperactivity disorder (ADHD) and the dopamine D4 receptor gene: evidence of association but no linkage in a UK sample", MOL PSYCHI, 6(4), 2001, pp. 440-444

Abstract

Recent studies report association and linkage between attention deficit hyperactivity disorder (ADHD) and the 7-repeat allele of a 48 base-pair repeat in the dopamine D4 receptor gene (DRD4).(1) We examined the frequency of this allele in a sample of probands with DSM-IV ADHD using a case-control design, as well as the transmission disequilibrium test (TDT) and haplotype-based haplotype relative risk (HHRR) in the subset of probands with DNA available from both parents. One hundred and thirty-two ADHD probands were compared with 189 controls (chi (2) = 6.17, 1 df, P = 0.01, OR = 1.73, 95% CI = 1.11-2.71). A total of 85 complete trios were available for within-familytests of association and linkage. Fifty-two heterozygous parents carrying one copy of the 7-repeat were informative for the TDT (29 transmitted vs 23non-transmitted, chi (2) = 0.69). Analysis of the entire sample of 132 probands using TRANSMIT(2) provided no additional evidence for excess transmission of the 7-repeat allele (58 transmitted vs 54 non-transmitted). HHRR gave similar results. We conclude that the case-control findings are likely to be falsely positive, resulting from genetic stratification. However we can not rule out alternative explanations of low statistical power and gene-environment correlation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 07:36:46