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Titolo:
Two dopamine genes related to reports of childhood retrospective inattention and conduct disorder symptoms
Autore:
Rowe, DC; Stever, C; Chase, D; Sherman, S; Abramowitz, A; Waldman, ID;
Indirizzi:
Univ Arizona, Grad Comm Genet, Tucson, AZ 85721 USA Univ Arizona Tucson AZ USA 85721 a, Grad Comm Genet, Tucson, AZ 85721 USA Univ Arizona, Div Family Studies & Human Dev, Tucson, AZ 85721 USA Univ Arizona Tucson AZ USA 85721 tudies & Human Dev, Tucson, AZ 85721 USA AOSIS Corp, Tempe, AZ 85281 USA AOSIS Corp Tempe AZ USA 85281AOSIS Corp, Tempe, AZ 85281 USA Univ Arizona, Dept Mol & Cellular Biol, Tucson, AZ 85721 USA Univ ArizonaTucson AZ USA 85721 ol & Cellular Biol, Tucson, AZ 85721 USA Emory Univ, Dept Psychiat, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 niv, Dept Psychiat, Atlanta, GA 30322 USA Emory Univ, Dept Psychol, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA30322 Univ, Dept Psychol, Atlanta, GA 30322 USA
Titolo Testata:
MOLECULAR PSYCHIATRY
fascicolo: 4, volume: 6, anno: 2001,
pagine: 429 - 433
SICI:
1359-4184(200107)6:4<429:TDGRTR>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEFICIT HYPERACTIVITY DISORDER; EXON-III POLYMORPHISM; TRANSPORTER GENE; RECEPTOR GENE; NOVELTY SEEKING; ASSOCIATION; METHYLPHENIDATE; AMPHETAMINE; POPULATION; CHILDREN;
Keywords:
association; dopamine transporter gene (DAT1); dopamine D4 receptor gene (DRD4); attention deficit hyperactivity disorder (ADHD); conduct disorder (CD);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Rowe, DC Univ Arizona, Grad Comm Genet, Campus Box 210033, Tucson, AZ 85721 USA Univ Arizona Campus Box 210033 Tucson AZ USA 85721 , AZ 85721 USA
Citazione:
D.C. Rowe et al., "Two dopamine genes related to reports of childhood retrospective inattention and conduct disorder symptoms", MOL PSYCHI, 6(4), 2001, pp. 429-433

Abstract

The 7-repeat allele of the dopamine receptor D4 gene (DRD4) and the 10 repeat allele of the dopamine transporter gene (DAT1) have shown association and linkage with symptoms of attention deficit hyperactivity disorder (ADHD)in childhood. The parents of ADHD children (clinic group, n = 80 fathers and 107 mothers) and control children (control group, n = 42 fathers and 51 mothers) were the focus of this study. These parents reported retrospectively on their level of ADHD Inattention and Conduct Disorder symptoms in adolescence. In analyses of the relation of symptom levels to the DRD4 and DAT1genotypes, fathers possessing the 7 repeat DRD4 allele had greater levels of both inattention and conduct disorder symptoms. Mothers with the 10/10 genotype had higher levels of inattention symptoms. Thus, genetic associations found in children may be replicable in their parents.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/01/20 alle ore 18:59:02