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Titolo:
Dopa decarboxylase gene polymorphisms and attention deficit hyperactivity disorder (ADHD): no evidence for association in the Irish population
Autore:
Hawi, Z; Foley, D; Kirley, A; McCarron, M; Fitzgerald, M; Gill, M;
Indirizzi:
Univ Dublin Trinity Coll, Dept Genet & Psychiat, Dublin 2, Ireland Univ Dublin Trinity Coll Dublin Ireland 2 & Psychiat, Dublin 2, Ireland
Titolo Testata:
MOLECULAR PSYCHIATRY
fascicolo: 4, volume: 6, anno: 2001,
pagine: 420 - 424
SICI:
1359-4184(200107)6:4<420:DDGPAA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINO-ACID DECARBOXYLASE; CHILDHOOD-ONSET; TRANSPORTER; CHILDREN; PROMOTERS; SEROTONIN; ADULTS; RISK; DNA;
Keywords:
attention deficit hyperactivity disorder (ADHD); dopamine; dopa decarboxylase; association; haplotype based haplotype relative risk (HHRR);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Hawi, Z Univ Dublin Trinity Coll, Dept Genet, Dublin 2, Ireland Univ Dublin Trinity Coll Dublin Ireland 2 net, Dublin 2, Ireland
Citazione:
Z. Hawi et al., "Dopa decarboxylase gene polymorphisms and attention deficit hyperactivity disorder (ADHD): no evidence for association in the Irish population", MOL PSYCHI, 6(4), 2001, pp. 420-424

Abstract

Dopa decarboxylase (DDC) is an enzyme which catalyses the decarboxylation of both dopa to dopamine and L-5 hydroxytryptophan to serotonin, Both catecholamines are major neurotransmitters of the mammalian nervous system. It has been suggested that genes involved in the dopaminergic system play a primary role in predisposing to attention deficit hyperactivity disorder (ADHD). In this study, the 4-bp insertion/deletion variant mapped to the first neuronally expressed exon 1 at the dopa decarboxylase gene and two microsatellite markers flanking the gene were investigated for possible association with ADHD. Using HHRR, we observed an increased transmission (though not significant) of the 4-bp insertion (allele 1) to ADHD cases (chi (2) = 2.72, P = 0.1, RR =1.25). However marginally significant excess transmission of allele 10 (213 bp) of the 3' microsatellite D7S2422 (similar to0.75 cM distal to dopa decarboxylase gene) was found (chi (2) = 4.2, P = 0.04, RR = 1.48). Interestingly, a haplotype containing both alleles is transmitted more frequently (chi (2) = 5, P = 0.025). Analysing data by the sex of transmitting parent showed a greater relative risk for paternal transmission of the 4-bp insertion allele and allele 10 of the D7S2422 (RR = 1.48 and 1.63 respectively). This provides preliminary evidence that this locus or a closely mapped DNA variant may be involved in the genetic susceptibility to ADHD. However, further studies are required to either confirm or refute these observations.

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Documento generato il 18/01/20 alle ore 14:06:24