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Titolo:
Proposed endophenotypes of dysthymia: evolutionary, clinical and pharmacogenomic considerations
Autore:
Niculescu, AB; Akiskal, HS;
Indirizzi:
Univ Calif San Diego, Sch Med, Dept Psychiat, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 ychiat, La Jolla, CA 92093 USA San Diego VA Healthcare Syst, Dept Psychiat, La Jolla, CA USA San Diego VAHealthcare Syst La Jolla CA USA Psychiat, La Jolla, CA USA
Titolo Testata:
MOLECULAR PSYCHIATRY
fascicolo: 4, volume: 6, anno: 2001,
pagine: 363 - 366
SICI:
1359-4184(200107)6:4<363:PEODEC>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAJOR DEPRESSION; CHARACTEROLOGICAL DEPRESSIONS; ATYPICAL DEPRESSION; GENDER DIFFERENCES; TEMPS-I; DISORDERS; FEATURES; PATHOPHYSIOLOGY; TEMPERAMENT; COMORBIDITY;
Keywords:
dysthymia; neurasthenia; pharmacogenomics; endophenotypes; genes; evolution; gender; serotonin; dopamine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Akiskal, HS VA Psychiat Serv 116A, 3350 La Jolla Village Dr, La Jolla, CA 92093 USA VA Psychiat Serv 116A 3350 La Jolla Village Dr La Jolla CA USA 92093
Citazione:
A.B. Niculescu e H.S. Akiskal, "Proposed endophenotypes of dysthymia: evolutionary, clinical and pharmacogenomic considerations", MOL PSYCHI, 6(4), 2001, pp. 363-366

Abstract

Dysthymia is highly prevalent-though underdiagnosed-occurring in at least 3% of the population. We conceptualize it as the clinical extension of adaptive traits that have developed during evolution to cope with stress and failure. A classification of dysthymias into anxious and anergic subtypes-andtheir putative association to bipolarity-is proposed. We further posit neurochemical and neurophysiological substrates for the two subtypes. A betterrecognition and understanding of dysthymic subtypes and their respective place in the affective spectrum will increase the proportion of people that may benefit from targeted treatments. It would also expand the pool of subjects that may be enrolled in genetic and pharmacogenomic research studies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 06:26:42