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Titolo:
The paradox of smooth muscle physiology
Autore:
Woodrum, DA; Brophy, CM;
Indirizzi:
Med Coll Georgia, Inst Mol Med & Genet, Augusta, GA 30912 USA Med Coll Georgia Augusta GA USA 30912 Med & Genet, Augusta, GA 30912 USA
Titolo Testata:
MOLECULAR AND CELLULAR ENDOCRINOLOGY
fascicolo: 1-2, volume: 177, anno: 2001,
pagine: 135 - 143
SICI:
0303-7207(20010525)177:1-2<135:TPOSMP>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT PROTEIN-KINASE; HEAT-SHOCK-PROTEIN; ALPHA-B-CRYSTALLIN; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR; FOCAL ADHESION KINASE; LIGHT CHAIN KINASE; SWISS 3T3 CELLS; CYCLIC-GMP; TYROSINE PHOSPHORYLATION; MYOSIN PHOSPHORYLATION;
Keywords:
contraction; relaxation; heat-shock protein (HSP); cGMP; cAMP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
87
Recensione:
Indirizzi per estratti:
Indirizzo: Brophy, CM Phoenix VAMC, 650 Indian Sch Rd CS112, Phoenix, AZ 85012 USA Phoenix VAMC 650 Indian Sch Rd CS112 Phoenix AZ USA 85012 2 USA
Citazione:
D.A. Woodrum e C.M. Brophy, "The paradox of smooth muscle physiology", MOL C ENDOC, 177(1-2), 2001, pp. 135-143

Abstract

Vascular smooth muscle tone is controlled by a balance between the cellular signaling pathways that mediate the generation of force (contraction) andthe release of force (relaxation). The signaling events that activate contraction include Ca2+-dependent myosin light chain phosphorylation. The signaling events that mediate relaxation include the removal of a contractile agonist (passive relaxation) and activation of cyclic nucleotide-dependent signaling pathways in the continued presence of a contractile agonist (active relaxation). The major questions that remain in contractile physiology include (1) how is tonic force maintained when intracellular Ca2+ levels and myosin light chain phosphorylation have returned to basal levels; and (2) what is the mechanism of cyclic nucleotide-dependent relaxation? This reviewfocuses on these specific controversies surrounding the molecular mechanisms of contraction and relaxation of vascular smooth muscle. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:41:24