Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Role of insulin and insulin receptor in learning and memory
Autore:
Zhao, WQ; Alkon, DL;
Indirizzi:
Johns Hopkins Univ, Blanchette Rockefeller Neurosci Inst, Rockville, MD 20858 USA Johns Hopkins Univ Rockville MD USA 20858 i Inst, Rockville, MD 20858 USA
Titolo Testata:
MOLECULAR AND CELLULAR ENDOCRINOLOGY
fascicolo: 1-2, volume: 177, anno: 2001,
pagine: 125 - 134
SICI:
0303-7207(20010525)177:1-2<125:ROIAIR>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIPPOCAMPAL SYNAPTIC PLASTICITY; GROWTH-FACTOR RECEPTORS; LONG-TERM POTENTIATION; RAT-BRAIN SYNAPTOSOMES; CENTRAL-NERVOUS-SYSTEM; METHYL-D-ASPARTATE; GENE-EXPRESSION; TYROSINE PHOSPHORYLATION; MESSENGER-RNA; PHOSPHATIDYLINOSITOL 3-KINASE;
Keywords:
Akt; Alzheimer's disease; Grb-2; learning; MAP kinase; memory; pp60c-src; protein kinase C; Shc;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
82
Recensione:
Indirizzi per estratti:
Indirizzo: Zhao, WQ Johns Hopkins Univ, Blanchette Rockefeller Neurosci Inst, 9601 Med Ctr Dr,Acad & Res Bldg,3rd Floor, Rockville, MD 20858 USA Johns Hopkins Univ 9601 Med Ctr Dr,Acad & Res Bldg,3rd Floor Rockville MD USA 20858
Citazione:
W.Q. Zhao e D.L. Alkon, "Role of insulin and insulin receptor in learning and memory", MOL C ENDOC, 177(1-2), 2001, pp. 125-134

Abstract

As one of the most extensively studied protein hormones, insulin and its receptor have been known to play key roles in a variety of important biological functions. Until recent years, the functions of insulin and insulin receptor (IR) in the central nervous system (CNS) have largely remained unclear. IR is abundantly expressed in several specific brain regions that governfundamental behaviors such as food intake, reproduction and high cognition. The IR from the periphery and CNS exhibit differences in both structure and function. In addition to that from the peripheral system, locally synthesized insulin in the brain has also been identified. Accumulated evidence has demonstrated that insulin/IR plays important roles in associative learning, as suggested by results from both interventive and correlative studies. Interruption of insulin production and IR activity causes deficits in learning and memory formation. Abnormal insulin/IR levels and activities are seen in Alzheimer's dementia, whereas administration of insulin significantlyimproves the cognitive performance of these patients. The synaptic bases for the action of insulin/IR include modifying neurotransmitter release processes at various types of presynaptic terminals and modulating the activities of both excitatory and inhibitory postsynaptic receptors such as NMDA and GABA receptors, respectively. At the molecular level, insulin/IR participates in regulation of learning and memory via activation of specific signaling pathways, one of which is shown to be associated with the formation of long-term memory and is composed of intracellular molecules including the she, Grb-r/SOS, Ras/Raf, and MEK/MAP kinases. Cross-talk with another IR pathway involving IRS1, PI3 kinase, and protein kinase C, as well as with the non-receptor tyrosine kinase pp60c-src, may also be associated with memory processing. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 05:30:31