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Titolo:
Concentrating hormones into secretory granules: layers of control
Autore:
Dannies, PS;
Indirizzi:
Yale Univ, Sch Med, Dept Pharmacol, New Haven, CT 06510 USA Yale Univ NewHaven CT USA 06510 Dept Pharmacol, New Haven, CT 06510 USA
Titolo Testata:
MOLECULAR AND CELLULAR ENDOCRINOLOGY
fascicolo: 1-2, volume: 177, anno: 2001,
pagine: 87 - 93
SICI:
0303-7207(20010525)177:1-2<87:CHISGL>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANS-GOLGI NETWORK; VASOACTIVE INTESTINAL PEPTIDE; ENDOCRINE-CELLS; ENDOPLASMIC-RETICULUM; PITUITARY-CELLS; PROTEIN; PATHWAY; PROLACTIN; STORAGE; APPARATUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Dannies, PS Yale Univ, Sch Med, Dept Pharmacol, 333 Cedar St, New Haven, CT 06510 USA Yale Univ 333 Cedar St New Haven CT USA 06510 en, CT 06510 USA
Citazione:
P.S. Dannies, "Concentrating hormones into secretory granules: layers of control", MOL C ENDOC, 177(1-2), 2001, pp. 87-93

Abstract

Soluble protein hormones are concentrated and stored in secretory granulesThe cisternal maturation model for transport of proteins through the Golgicomplex allows a major role for formation of reversible aggregates as a means of both concentrating and sorting hormones, since soluble proteins willbe removed in small vesicles, leaving behind the aggregated hormones. The storage of secretory granule proteins, however, is more selective than would be expected if passive aggregation were the only process involved. Aggregation of hormones in the secretory pathway may not be completely passive, but may be controlled by the cells. In addition to aggregation, other layersof sorting must exist, because there is selective retention of proteins after aggregation or packaging into granules. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 12:23:11