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Titolo:
ANPs effect on MARCKS and StAR phosphorylation in agonist-stimulated glomerulosa cells
Autore:
Calle, RA; Bollag, WB; White, S; Betancourt-Calle, S; Kent, P;
Indirizzi:
Med Coll Georgia, Inst Mol Med & Genet, Program Cell Signaling, Augusta, GA 30912 USA Med Coll Georgia Augusta GA USA 30912 ll Signaling, Augusta, GA 30912 USA Med Coll Georgia, Dept Cellular Biol & Anat, Augusta, GA 30912 USA Med Coll Georgia Augusta GA USA 30912 Biol & Anat, Augusta, GA 30912 USA Augusta Vet Affairs Med Ctr, Dept Endocrinol, Augusta, GA USA Augusta Vet Affairs Med Ctr Augusta GA USA t Endocrinol, Augusta, GA USA
Titolo Testata:
MOLECULAR AND CELLULAR ENDOCRINOLOGY
fascicolo: 1-2, volume: 177, anno: 2001,
pagine: 71 - 79
SICI:
0303-7207(20010525)177:1-2<71:AEOMAS>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATRIAL-NATRIURETIC-PEPTIDE; PROTEIN-KINASE-C; BOVINE ADRENAL GLOMERULOSA; MEDIATED ALDOSTERONE SECRETION; ANGIOTENSIN-II; SIGNAL-TRANSDUCTION; LEYDIG-CELLS; CALCIUM; ACTIVATION; HORMONE;
Keywords:
aldosterone; adrenal glomerulosa; angiotensin II; potassium; myristoylated alanine-rich C-kinase substrate; steroidogenic acute regulatory protein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Calle, RA Med Coll Georgia, Inst Mol Med & Genet, Program Cell Signaling, CB-2801,1120 15th St, Augusta, GA 30912 USA Med Coll Georgia CB-2801,1120 15th St Augusta GA USA 30912 2 USA
Citazione:
R.A. Calle et al., "ANPs effect on MARCKS and StAR phosphorylation in agonist-stimulated glomerulosa cells", MOL C ENDOC, 177(1-2), 2001, pp. 71-79

Abstract

Atrial natriuretic peptide (ANP) is a cardiac hormone that inhibits aldosterone secretion induced by all physiologic agonists. The purpose of this study is to explore ANP-induced changes in the phosphorylation of myristoylated alanine-rich C-kinase substrate (MARCKS) and the steroidogenic acute regulatory protein (StAR), in AngII or K+-stimulated glomerulosa cells. The data show that ANP completely inhibits the phosphorylation of MARCKS and partially inhibits that of StAR in cells stimulated with K+. ANP also partiallyinhibits MARCKS phosphorylation but does not affect StAR phosphorylation in cells stimulated with AngII. These effects appear to be cGMP-independent and at least partially dependent on inhibition of protein kinase C (PKC). To our knowledge, this is the first report of ANP modulating either MARCKS or StAR phosphorylation in [P-32]-labeled cells. The data also support the hypothesis that ANP inhibits aldosterone secretion acting as a step involvedin cholesterol transport to the mitochondria. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

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Documento generato il 06/04/20 alle ore 07:48:18