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Titolo:
Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family
Autore:
Richter, BWM; Mir, SS; Eiben, LJ; Lewis, J; Reffey, SB; Frattini, A; Tian, L; Frank, S; Youle, RJ; Nelson, DL; Notarangelo, LD; Vezzoni, P; Fearnhead, HO; Duckett, CS;
Indirizzi:
NCI, Metab Branch, Div Clin Sci, NIH, Bethesda, MD 20892 USA NCI BethesdaMD USA 20892 anch, Div Clin Sci, NIH, Bethesda, MD 20892 USA NINDS, Surg Neurol Branch, NIH, Bethesda, MD 20892 USA NINDS Bethesda MD USA 20892 rg Neurol Branch, NIH, Bethesda, MD 20892 USA NCI, Frederick Canc Res & Dev Ctr, NIH, Frederick, MD USA NCI Frederick MD USA rederick Canc Res & Dev Ctr, NIH, Frederick, MD USA CNR, Ist Tecnol Biomed Avanzate, I-20131 Milan, Italy CNR Milan Italy I-20131 Ist Tecnol Biomed Avanzate, I-20131 Milan, Italy Univ Brescia, Dept Pediat, Brescia, Italy Univ Brescia Brescia ItalyUniv Brescia, Dept Pediat, Brescia, Italy
Titolo Testata:
MOLECULAR AND CELLULAR BIOLOGY
fascicolo: 13, volume: 21, anno: 2001,
pagine: 4292 - 4301
SICI:
0270-7306(200107)21:13<4292:MCOIAN>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ONCOGENE-DEPENDENT APOPTOSIS; CYTOCHROME-C; CASPASE ACTIVATION; NEGATIVE REGULATION; APAF-1 APOPTOSOME; IAP GENES; KAPPA-B; XIAP; BCL-X(L); COMPLEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Duckett, CS NCI, Metab Branch, Div Clin Sci, NIH, 10 Ctr Dr,Room 6B-05, Bethesda, MD 20892 USA NCI 10 Ctr Dr,Room 6B-05 Bethesda MD USA 20892 a, MD 20892 USA
Citazione:
B.W.M. Richter et al., "Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family", MOL CELL B, 21(13), 2001, pp. 4292-4301

Abstract

Inhibitor of apoptosis protein (IAP)-like protein-1 (ILP-1) (also known asX-linked IAP [XIAP] and mammalian IAP homolog A [MIHA]) is a potent inhibitor of apoptosis and exerts its effects, at least in part, by the direct association with and inhibition of specific caspases. Here, we describe the molecular cloning and characterization of a human gene related to ILP-1, termed ILP-2. Despite high homology to ILP-1, ILP-2 is encoded by a distinct gene, which in normal tissues is expressed solely in testis. In contrast to ILP-1, overexpression of ILP-2 had no protective effect on apoptosis mediated by Fas (also known as: CD95) or tumor necrosis factor. However, ILP-2 potently inhibited apoptosis induced by overexpression of Bax or by coexpression of caspase 9 with Apaf-1, and preincubation of cytosolic extracts with ILP-2 abrogated caspase activation in vitro. A processed form of caspase 9 could be coprecipitated with ILP-2 from cells, suggesting a physical interaction between ILP-2 and caspase 9. Thus, ILP-2 is a novel IAP family memberwith restricted specificity for caspase 9.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 21:03:43