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Titolo:
The mucin-like glycoprotein super-family of Trypanosoma cruzi: structure and biological roles
Autore:
Acosta-Serrano, A; Almeida, IC; Freitas, LH; Yoshida, N; Schenkman, S;
Indirizzi:
Johns Hopkins Univ, Sch Med, Dept Biol Chem, Baltimore, MD 21205 USA JohnsHopkins Univ Baltimore MD USA 21205 l Chem, Baltimore, MD 21205 USA Univ Sao Paulo, ICB2, Dept Parasitol, BR-05508900 Sao Paulo, Brazil Univ Sao Paulo Sao Paulo Brazil BR-05508900 BC05508900 Sao Paulo, Brazil UNIFESP, Escola Paulista Med, Dept Microbiol Immunol & Parasitol, BR-04023062 Sao Paulo, Brazil UNIFESP Sao Paulo Brazil BR-04023062 BCol, BR-04023062 Sao Paulo, Brazil
Titolo Testata:
MOLECULAR AND BIOCHEMICAL PARASITOLOGY
fascicolo: 2, volume: 114, anno: 2001,
pagine: 143 - 150
SICI:
0166-6851(200105)114:2<143:TMGSOT>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
HOST-CELL INVASION; ALPHA-GALACTOSYL ANTIBODIES; SURFACE TRANS-SIALIDASE; CHRONIC CHAGAS-DISEASE; METACYCLIC TRYPOMASTIGOTES; MEDIATES RESISTANCE; EPIMASTIGOTE FORMS; ADHESION MOLECULE; MAMMALIAN-CELLS; ACID;
Keywords:
Trypanosoma cruzi; mucins; sialic acid; trans-sialidase; GPI; glycosylation;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Acosta-Serrano, A Univ Dundee, Sch Life Sci, Wellcome Trust Bioctr, Div Mol Microbiol & BiolChem, Dundee DD1 5EH, Scotland Univ Dundee Dundee Scotland DD1 5EH DD1 5EH, Scotland
Citazione:
A. Acosta-Serrano et al., "The mucin-like glycoprotein super-family of Trypanosoma cruzi: structure and biological roles", MOL BIOCH P, 114(2), 2001, pp. 143-150

Abstract

Trypanosoma cruzi expresses at its surface large amounts of mucin-like glycoproteins. The T. cruzi mucins (TcMUC), a group of highly glycosylated GPI-anchored proteins rich in Thr, Ser, and Pro residues, are expressed in high copy numbers in both insect and mammalian stages of the parasite. These molecules are encoded by a multigene family and contain a unique type of glycosylation consisting of several sialylated O-glycans linked to the proteinbackbone via Nw-acetylglucosamine residues. The TcMUC are important because of their role in host cell invasion and the ability to induce secretion of proinflammatory cytokines and nitric oxide in activated macrophages. The TcMUC are also significant in being the major substrate For the cell surface trans-sialidase. In this review, we summarize the recent knowledge on themolecular structure and function of this family of T. cruzi glycoproteins. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 18:05:54