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Titolo:
Microglia in neurodegeneration: Molecular aspects
Autore:
Gebicke-Haerter, PJ;
Indirizzi:
Cent Inst Mental Hlth, Dept Psychopharmacol, D-68159 Mannheim, Germany Cent Inst Mental Hlth Mannheim Germany D-68159 D-68159 Mannheim, Germany
Titolo Testata:
MICROSCOPY RESEARCH AND TECHNIQUE
fascicolo: 1, volume: 54, anno: 2001,
pagine: 47 - 58
SICI:
1059-910X(20010701)54:1<47:MINMA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; CULTURED RAT MICROGLIA; CENTRAL-NERVOUS-SYSTEM; TUMOR-NECROSIS-FACTOR; MESSENGER-RNA EXPRESSION; GROWTH-FACTOR-BETA; MYELIN BASIC-PROTEIN; NF-KAPPA-B; INTERCELLULAR-ADHESION MOLECULE-1; PEPTIDES INHIBIT PRODUCTION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
173
Recensione:
Indirizzi per estratti:
Indirizzo: Gebicke-Haerter, PJ Cent Inst Mental Hlth, Dept Psychopharmacol, J5, D-68159 Mannheim, Germany Cent Inst Mental Hlth J5 Mannheim Germany D-68159 any
Citazione:
P.J. Gebicke-Haerter, "Microglia in neurodegeneration: Molecular aspects", MICROSC RES, 54(1), 2001, pp. 47-58

Abstract

Inflammatory events in the CNS are associated with injuries as well as with well-known chronic degenerative diseases, such as Multiple Sclerosis, Parkinson's, or Alzheimer's disease. Compared to inflammation in peripheral tissues, inflammation in brain appears to follow distinct pathways and time-courses, which likely has to do with a relatively strong immunosuppression in that organ. For this reason, it is of great importance to get insights into the molecular mechanism governing immune reactions in brain tissue. Thistask is hard to achieve in vivo, but can be approached by studying the major cell type responsible for brain inflammation, the microglia, in culture. Since these cells are the only professional antigen-presenting cells resident in brain parenchyma, molecular mechanisms of antigen presentation are being discussed first. After covering the expression and regulation of anti-and proinflammatory cytokines, induction and regulation of two key enzymesand their products-COX-2 and iNOS-are summarized. Possibly, pivotal molecular targets for drug therapies of brain disorders will be discovered in intracellular signaling pathways leading to activation of transcription factors. Finally, the impact of growth factors, of neurotrophins in particular, is highlighted. It is concluded that the presently available data on the molecular level is far from being statisfying, but that only from better insights into molecular events will we obtain the information required for more specific therapies. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:53:25