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Titolo:
Ion channels in cultured microglia
Autore:
Walz, W; Bekar, LK;
Indirizzi:
Univ Saskatchewan, Dept Physiol, Saskatoon, SK S7N 05E5, Canada Univ Saskatchewan Saskatoon SK Canada S7N 05E5 atoon, SK S7N 05E5, Canada
Titolo Testata:
MICROSCOPY RESEARCH AND TECHNIQUE
fascicolo: 1, volume: 54, anno: 2001,
pagine: 26 - 33
SICI:
1059-910X(20010701)54:1<26:ICICM>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATED RAT MICROGLIA; CORPUS-CALLOSUM SLICE; OUTWARD K+ CURRENTS; POTASSIUM CHANNELS; MOUSE-BRAIN; ELECTROPHYSIOLOGICAL PROPERTIES; EXTRACELLULAR ATP; MEMBRANE CURRENTS; HUMAN MACROPHAGES; CL CHANNELS;
Keywords:
activation; chloride currents; migration; potassium currents; proliferation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Walz, W Univ Saskatchewan, Dept Physiol, 107 Wiggins Rd, Saskatoon, SK S7N05E5, Canada Univ Saskatchewan 107 Wiggins Rd Saskatoon SK Canada S7N 05E5nada
Citazione:
W. Walz e L.K. Bekar, "Ion channels in cultured microglia", MICROSC RES, 54(1), 2001, pp. 26-33

Abstract

Inward and, depending on activation state, outward potassium currents are the dominant ion channels in microglial cells in culture, During transitionbetween resting and activated phases, there is also an upregulated expression of stretch/swelling-activated chloride currents. Pharmacological blockade of the specific potassium channels does not prevent the transition, whereas blockade of chloride channels does, suggesting that this current may beinvolved in phase changes. Interestingly, this chloride current is far less studied than the potassium currents with regard to the different microglial phases. One puzzling finding when studying microglial state is that despite changes in current densities and membrane oscillations during transition, there is no evidence of an accompanying change in membrane potential. Inother cells of the immune system, membrane oscillations and alterations inmembrane potential are correlated with transitions in cellular phases. This discrepancy in microglia may be a result of the fact that almost all ion channel and membrane potential studies in culture are undertaken with concomitant dialysis of cytoplasm with pipette solution. Further complicating matters is that the few studies that use microglia in situ, find fundamental differences in ion channel current patterns of "resting" microglia as well as different temporal changes to pathological events or stimuli. (C) 2001 Wiley-Liss. Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 18:32:15