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Titolo:
Dose response and coagulation and hemostatic factors
Autore:
Rauramaa, R; Li, G; Vaisanen, SB;
Indirizzi:
Kuopio Res Inst Exercise Med, FIN-70100 Kuopio, Finland Kuopio Res Inst Exercise Med Kuopio Finland FIN-70100 00 Kuopio, Finland Univ Kuopio, Dept Physiol, FIN-70211 Kuopio, Finland Univ Kuopio Kuopio Finland FIN-70211 Physiol, FIN-70211 Kuopio, Finland Kuopio Univ Hosp, Dept Clin Physiol & Nucl Med, SF-70210 Kuopio, Finland Kuopio Univ Hosp Kuopio Finland SF-70210 l Med, SF-70210 Kuopio, Finland Kuopio Univ Hosp, Dept Clin Chem, SF-70210 Kuopio, Finland Kuopio Univ Hosp Kuopio Finland SF-70210 Chem, SF-70210 Kuopio, Finland
Titolo Testata:
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
fascicolo: 6, volume: 33, anno: 2001, supplemento:, S
pagine: S516 - S520
SICI:
0195-9131(200106)33:6<S516:DRACAH>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMINOGEN-ACTIVATOR INHIBITOR-1; RANDOMIZED CLINICAL-TRIAL; CORONARY-ARTERY DISEASE; MYOCARDIAL-INFARCTION; FIBRINOLYTIC-ACTIVITY; STRENUOUS EXERCISE; PLASMA-FIBRINOGEN; PLATELET-FUNCTION; CARDIOVASCULAR-DISEASE; POSTMENOPAUSAL WOMEN;
Keywords:
exercise training; controlled randomized clinical trial; platelet function; blood coagulation; fibrinolysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Rauramaa, R Kuopio Res Inst Exercise Med, Haapaniementie 16, FIN-70100 Kuopio, Finland Kuopio Res Inst Exercise Med Haapaniementie 16 Kuopio FinlandFIN-70100
Citazione:
R. Rauramaa et al., "Dose response and coagulation and hemostatic factors", MED SCI SPT, 33(6), 2001, pp. S516-S520

Abstract

Purpose: The purpose of this study was to evaluate the dose-response relations of regular physical activity on platelet function, blood coagulation factors, and fibrinolytic factors, on the basis of studies with appropriate experimental design, Methods: MEDLINE-based literature search supplemented with relevant review articles and other individual articles was used. The review concentrates on controlled randomized clinical trials on the impact of regular physical exercise on platelet function, and on blood coagulation and fibrinolytic factors. Results: Physical exercise acutely activates platelets and the fibrinolytic system and some factors of the blood coagulationcascade. These findings, the earliest of which were published already in the 1960s, are mainly derived from uncontrolled observations. These studies have led to the conclusion that unbalanced activation of the hemostatic system during acute exercise may be part of the mechanisms for sudden cardiac events during or shortly after heavy physical exercise. The effects of regular physical exercise on various aspects of platelet function, blood coagulation, and fibrinolysis have been the object in only a few controlled randomized trials. With the exception of data on platelet function, the results remain contradictory. Conclusion: Controlled randomized clinical trials with adequate statistical power and experimental study designs with subjects of different ages and health status are warranted for the evaluation of the dose-response issues to clearly delineate the preventive and therapeutic potential of regular physical exercise.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/10/20 alle ore 03:44:08