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Titolo:
Serum CagA and VacA antibodies and risk for peptic ulcer disease in subjects with Helicobacter pylori infection
Autore:
Santolaria, S; Lanas, A; Benito, R; Piazuelo, E; Sainz, R;
Indirizzi:
Univ Zaragoza, Hosp Lozano Blesa, Serv Aparato Digest, Zaragoza, Spain Univ Zaragoza Zaragoza Spain lesa, Serv Aparato Digest, Zaragoza, Spain Univ Zaragoza, Hosp Lozano Blesa, Microbiol Serv, Zaragoza, Spain Univ Zaragoza Zaragoza Spain ano Blesa, Microbiol Serv, Zaragoza, Spain
Titolo Testata:
MEDICINA CLINICA
fascicolo: 17, volume: 116, anno: 2001,
pagine: 641 - 644
SICI:
0025-7753(20010512)116:17<641:SCAVAA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
SPA
Soggetto:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; GASTRIC-CANCER; SEROLOGIC DETECTION; CLINICAL RELEVANCE; VIRULENCE FACTORS; DUODENAL-ULCERS; HIGH PREVALENCE; NSAID USERS; STRAINS; OMEPRAZOLE;
Keywords:
Helicobacter pylori; CagA; VacA; non-steroidal antiinflammatory drugs; peptic ulcer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Santolaria, S Hosp San Jorge, Secc Aparato Digest, Avda Martinex Velasco,S-N, Huesca 22004, Spain Hosp San Jorge Avda Martinex Velasco,S-N Huesca Spain 22004
Citazione:
S. Santolaria et al., "Serum CagA and VacA antibodies and risk for peptic ulcer disease in subjects with Helicobacter pylori infection", MED CLIN, 116(17), 2001, pp. 641-644

Abstract

BACKGROUND: The presence of cagA antibodies constitutes a serum marker of infection caused by virulent strains of Helicobacter pylori. The objective of this study was to determine the risk of peptic ulcer in patients with H.pylori infection, in relation to the detection of CagA and VacA antibodies,PATIENTS AND METHOD: Prospective case-control study including 104 peptic ulcer patients with active H. pylori infection (positive urease test and/or histology, or positive urea breath test) and 104 age- and sex-matched controls, without peptic ulcer history, with active H. pylori infection (positive urea breath test), Serum CagA and VacA antibodies were determined by Western blot. Non-steroidal antiinflamatory drugs (NSAID) use was determined bystructured data collection. A multivariate analysis (logistic regression) was carried out to determine the odds ratio (OR). RESULTS: Presence of serum antibodies against CagA was higher in peptic ulcer patients (74%) than in controls (46.2%) (OR = 5.7; 95% CI = 2.1-15.6). However, presence of serum antibodies against VacA in patients (46.2%) was similar to that in controls (36.5%). NSAID use was also more frequent in patients (51.9%) than in controls (21.2%) (OR = 6.5; 95% CI = 2.2-19.5). CONCLUSIONS: Serum antibodies against CagA and use of NSAID are the most important risk factors for peptic ulcer disease.

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Documento generato il 06/04/20 alle ore 01:48:17